{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:39:23Z","timestamp":1789007963913,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T00:00:00Z","timestamp":1518393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A distinctive eruption referred to as \u2018insect bite\u2010like reaction\u2019 or \u2018eosinophilic dermatosis of haematological malignancy\u2019 has been described during the course of haematological B\u2010cell malignancies (<jats:styled-content style=\"fixed-case\">BCM<\/jats:styled-content>). However, its clinical evolution, histopathological features and pathogenesis remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To characterize this eruption and to investigate its pathogenesis and relationship with the underlying <jats:styled-content style=\"fixed-case\">BCM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this multicenter retrospective study of the French Study Group on Cutaneous Lymphomas, 37 patients with a <jats:styled-content style=\"fixed-case\">BCM<\/jats:styled-content> and a cutaneous eruption consisting in chronic and\/or recurrent papules, papulo\u2010vesicles and\/or nodules were included. Clinical, histopathological, immunohistochemical and molecular data were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant insect bite history or seasonal predominance was recorded. Patients had pruritic papules (81%), papulo\u2010vesicles (43%) and nodules (38%), often predominated in the head and neck region (84%), without complete remission periods in most cases (57%). The predominant associated <jats:styled-content style=\"fixed-case\">BCM<\/jats:styled-content> was chronic lymphocytic leukaemia (73%). Histological and immunohistochemical review showed a dense dermal lymphocytic infiltrate predominantly composed of T lymphocytes (100%), with frequent eosinophils (77.6%); a perivascular and periadnexal (most often folliculotropic) pattern (77.6%), sometimes suggestive of a folliculotropic mycosis fungoides; clusters of tumour B cells were identified in 47% of cases using appropriate phenotyping markers. In 10\/14 cases (71.4%) tested for B\u2010cell IgH gene rearrangement, a B\u2010cell clone was identified in skin lesions (identical to the blood clone in nine cases), whereas no T\u2010cell clone was present.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We propose the denomination \u2018T\u2010cell papulosis associated with B\u2010cell malignancy\u2019 (<jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BCM<\/jats:styled-content>) for this distinctive eruption. Although resulting in various histopathological pictures, it can be easily recognized by clinicians and may be identified by informed pathologists relying on some key features. An extravasation of tumour B cells with skin\u2010homing properties associated with a secondary, predominant, T\u2010cell immune reaction could explain the clinicopathologic aspect and the prolonged regressive and recurrent course of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14805","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T15:26:44Z","timestamp":1516634804000},"page":"1469-1475","source":"Crossref","is-referenced-by-count":25,"title":["T\u2010cell papulosis associated with B\u2010cell malignancy: a distinctive clinicopathologic entity"],"prefix":"10.1111","volume":"32","author":[{"given":"L.","family":"Visseaux","sequence":"first","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Robert Debr\u00e9 Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Durlach","sequence":"additional","affiliation":[{"name":"Laboratoire Pol Bouin H\u00f4pital Maison Blanche Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Barete","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Beylot\u2010Barry","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Saint\u2010Andr\u00e9 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Dermatologie Institut Paoli Calmettes Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chassine","sequence":"additional","affiliation":[{"name":"Cabinet de Dermatologie Prouzel France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Franck","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Cochin Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Herve","sequence":"additional","affiliation":[{"name":"Service de Pathologie H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Leclec'h","sequence":"additional","affiliation":[{"name":"Service de Dermatologie CHU d'Angers Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Machet","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Trousseau Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ingen\u2010Housz\u2010Oro","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Henri Mondor Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Petrella","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology University of Montr\u00e9al Montr\u00e9al Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Vergier","sequence":"additional","affiliation":[{"name":"Service de Pathologie H\u00f4pital Haut\u2010Lev\u00eaque Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ortonne","sequence":"additional","affiliation":[{"name":"Service de Pathologie H\u00f4pital Henri Mondor Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Grange","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Robert Debr\u00e9 Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190601137336"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12201"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V26.3.257.257"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.12.1503"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2010.02.001"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2012.01906.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12454"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/archderm.1996.03890300111015","article-title":"Pilotropic cutaneous T\u2010cell lymphoma without mucinosis. 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