{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:20:21Z","timestamp":1790814021629,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"departmental resources"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Topical capsaicin shows efficacy in the treatment of brachioradial pruritus (BRP); however, its mechanisms of action remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The effect of capsaicin on the epidermis (i.e. peripheral expression of non\u2010neuronal sensory receptors on keratinocytes, morphological changes in innervation) is still unknown. We aimed to investigate the effect of topical capsaicin on keratinocyte expression of <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content> channels and on the intraepidermal nerve fibre density (<jats:styled-content style=\"fixed-case\">IENFD<\/jats:styled-content>) in patients with BRP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010one patients with BRP received an 8% capsaicin patch. Biopsies in lesional and non\u2010lesional skin were taken to assess epidermal morphology, keratinocyte expression of <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content> channels and <jats:styled-content style=\"fixed-case\">IENFD<\/jats:styled-content> before and 3 weeks after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with the capsaicin patch led to a significant decrease in itch and paresthetic symptoms (<jats:italic>P<\/jats:italic> &lt; 0.05). Keratinocyte morphology is unaltered after capsaicin therapy. Reduced keratinocyte expression of <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>1 in lesional skin (<jats:italic>P<\/jats:italic> = 0.009; <jats:italic>n<\/jats:italic> = 9) normalized 3 weeks after treatment (<jats:italic>P<\/jats:italic> = 0.016; <jats:italic>n<\/jats:italic> = 10), but not the <jats:styled-content style=\"fixed-case\">IENFD<\/jats:styled-content>, which remained reduced in lesional epidermis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The normalization of the decreased <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>1 expression may account for the effectiveness of topical capsaicin, which does not reconstitute the reduced <jats:styled-content style=\"fixed-case\">IENFD<\/jats:styled-content>, arguing for a role of epidermal <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>1 in the maintenance of BRP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14857","type":"journal-article","created":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T10:44:38Z","timestamp":1518259478000},"page":"1535-1541","source":"Crossref","is-referenced-by-count":23,"title":["Application of an 8% capsaicin patch normalizes epidermal <scp>TRPV<\/scp>1 expression but not the decreased intraepidermal nerve fibre density in patients with brachioradial pruritus"],"prefix":"10.1111","volume":"32","author":[{"given":"M.P.","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Dermatology and Center for Chronic Pruritus University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"L\u00fcling","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Center for Chronic Pruritus University Hospital M\u00fcnster M\u00fcnster 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