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Current clinical paradigms for the treatment of psoriasis have evolved to include targeted biologic therapies, starting with tumour necrosis factor\u2010alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) inhibitors and later, agents targeting interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201012\/23 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017. The most recent evidence suggests that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 might be an even more potent target for the effective treatment of psoriasis and other autoimmune inflammatory disorders. This review will describe recent developments leading to the current understanding of the key role of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 as a \u2018master regulator\u2019 of autoimmune inflammation and the clinical evidence for agents that specifically target this modulator in the context of treating psoriasis, spondyloarthropathy and inflammatory bowel disease.<\/jats:p>","DOI":"10.1111\/jdv.14868","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T19:46:56Z","timestamp":1518551216000},"page":"1111-1119","source":"Crossref","is-referenced-by-count":106,"title":["Shifting the focus \u2013 the primary role of <scp>IL<\/scp>\u201023 in psoriasis and other inflammatory disorders"],"prefix":"10.1111","volume":"32","author":[{"given":"M.J.","family":"Gooderham","sequence":"first","affiliation":[{"name":"SKiN Centre for Dermatology Probity Medical Research Queen's University Peterborough ON 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