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This second part of the guideline covers antimicrobial therapy, systemic treatment, allergen\u2010specific immunotherapy, complementary medicine, psychosomatic counselling and educational interventions, whereas the first part covers methods, patient perspective, general measures and avoidance strategies, basic emollient treatment and bathing, dietary intervention, topical anti\u2010inflammatory therapy, phototherapy and antipruritic therapy. Management of AE must consider the individual clinical variability of the disease. Systemic immunosuppressive treatment with cyclosporine, methotrexate, azathioprine and mycophenolic acid is established option for severe refractory cases, and widely available. Biologicals targeting the T helper 2 pathway such as dupilumab may be a safe and effective, disease\u2010modifying alternative when available. Oral drugs such as JAK inhibitors and histamine 4 receptor antagonists are in development. Microbial colonization and superinfection may cause disease exacerbation and can require additional antimicrobial treatment. Allergen\u2010specific immunotherapy with aeroallergens may be considered in selected cases. Psychosomatic counselling is recommended especially in stress\u2010induced exacerbations. Therapeutic patient education (\u2018Eczema school\u2019) is recommended for children and adult patients. 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