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It is a consensus\u2010based guideline, taking available evidence from other guidelines, systematic reviews and published studies into account. This first part of the guideline covers methods, patient perspective, general measures and avoidance strategies, basic emollient treatment and bathing, dietary intervention, topical anti\u2010inflammatory therapy, phototherapy and antipruritic therapy, whereas the second part covers antimicrobial therapy, systemic treatment, allergen\u2010specific immunotherapy, complementary medicine, psychosomatic counselling and educational interventions. Management of\n                    <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>\n                    must consider the individual clinical variability of the disease; highly standardized treatment rules are not recommended. Basic therapy is focused on treatment of disturbed barrier function by hydrating and lubricating topical treatment, besides further avoidance of specific and unspecific provocation factors. Topical anti\u2010inflammatory treatment based on glucocorticosteroids and calcineurin inhibitors is used for flare management and for proactive therapy for long\u2010term control. Topical corticosteroids remain the mainstay of therapy, whereas tacrolimus and pimecrolimus are preferred in sensitive skin areas and for long\u2010term use. Topical phosphodiesterase inhibitors may be a treatment alternative when available. Adjuvant therapy includes\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    irradiation, preferably with\n                    <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\n                    311\u00a0nm or\n                    <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\n                    1. Pruritus is targeted with the majority of the recommended therapies, but some patients may need additional antipruritic therapy. Antimicrobial therapy, systemic anti\u2010inflammatory treatment, immunotherapy, complementary medicine and educational intervention will be addressed in part\n                    <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                    of the guideline.\n                  <\/jats:p>","DOI":"10.1111\/jdv.14891","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T08:05:14Z","timestamp":1524211514000},"page":"657-682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":871,"title":["Consensus\u2010based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I"],"prefix":"10.1111","volume":"32","author":[{"given":"A.","family":"Wollenberg","sequence":"first","affiliation":[{"name":"Department Dermatology and Allergy Ludwig\u2010Maximilian University Munich Germany"},{"name":"Klinik Thalkirchner Stra\u00dfe Munich 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