{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:24:43Z","timestamp":1791915883948,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The association between chronic inflammatory diseases, such as rheumatoid arthritis and psoriasis, and insulin resistance (IR) has been well established. Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease that affects the apocrine gland\u2010bearing areas of the body.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to determine the prevalence of IR in patients with HS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional, case\u2013control study enrolled 137 subjects, 76 patients with HS and 61 age\u2010 and gender\u2010matched controls. Demographic data, clinical examination of HS patients, anthropometric measures, cardiovascular risk factors and laboratory studies were recorded. The homeostasis model assessment of IR (HOMA\u2010IR) was calculated in all participants by measuring fasting plasma glucose and insulin levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median (IQR) HOMA\u2010IR value in HS patients was significantly higher [2.0 (1.0\u20133.6)] than in controls [1.5 (0.9\u20132.3)] (<jats:italic>P<\/jats:italic> = 0.01). The prevalence of IR was significantly higher in cases (43.4%) compared with controls (16.4%) (<jats:italic>P<\/jats:italic> = 0.001). In the linear regression multivariable analysis after adjusting for age, sex and body mass index (BMI), HS remained as a significant factor for a higher HOMA\u2010IR [2.51 (0.18) vs 1.92(0.21); <jats:italic>P<\/jats:italic> = 0.04]. The HOMA\u2010IR value and the prevalence of IR did not differ significantly among HS patients grouped by severity of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results show an increased frequency of IR in HS. Thus, we suggest HS patients to be evaluated for IR and managed accordingly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14894","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T13:06:36Z","timestamp":1519736796000},"page":"820-824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Insulin resistance in hidradenitis suppurativa: a case\u2013control study"],"prefix":"10.1111","volume":"32","author":[{"given":"I.","family":"Vilanova","sequence":"first","affiliation":[{"name":"Division of Dermatology Hospital Universitario Marques de Valdecilla IDIVAL University of Cantabria Santander Cantabria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Hospital Universitario Marques de Valdecilla IDIVAL University of Cantabria Santander Cantabria 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