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Affecting any age and race, GPP can occur with other forms of psoriasis or by itself. Stimuli for flares include medications, infections and environmental triggers. The interleukin family and caspase recruitment domain family have been implicated in its pathogenesis. Other forms of pustular psoriasis include impetigo herpetiformis, palmoplantar pustular psoriasis, annular pustular psoriasis and acrodermatitis continua of Hallopeau. Treatment is not well established, but includes the use of retinoids, methotrexate, cyclosporine, corticosteroids,\n                    <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                    \u2010alpha inhibitors, topical therapy and phototherapy. The use of\n                    <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                    \u2010alpha inhibitors may result in the formation of antidrug antibodies and should be administered with methotrexate.\n                  <\/jats:p>","DOI":"10.1111\/jdv.14949","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T19:38:56Z","timestamp":1521920336000},"page":"1645-1651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":179,"title":["Generalized pustular psoriasis: a review and update on treatment"],"prefix":"10.1111","volume":"32","author":[{"given":"K.M.","family":"Hoegler","sequence":"first","affiliation":[{"name":"Department of Dermatology Rutgers\u2010New Jersey Medical School Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"John","sequence":"additional","affiliation":[{"name":"Department of Dermatology 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