{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:31:55Z","timestamp":1792859515224,"version":"4.5.0"},"reference-count":10,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001422"],"award-info":[{"award-number":["UL1TR001422"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Although literature demonstrates a decreased risk of Alzheimer's disease (\n AD<\/jats:styled-content>\n ) in individuals with various cancers, including squamous cell cancers (\n SCC<\/jats:styled-content>\n ) and basal cell cancers (\n BCC<\/jats:styled-content>\n ) comprising non\u2010melanoma skin cancers (\n NMSC<\/jats:styled-content>\n ), there is a paucity of literature to substantiate an association between malignant melanoma (\n MM<\/jats:styled-content>\n ) and\n AD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n The aim of this study was to determine whether an association exists between\n MM<\/jats:styled-content>\n and\n AD<\/jats:styled-content>\n as well as for\n NMSC<\/jats:styled-content>\n and\n AD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A large urban, Midwestern,\n US<\/jats:styled-content>\n , single\u2010centre, medical record (\n EMR<\/jats:styled-content>\n ) data repository was searched between January 2001 and December 2015, to identify all patients at age \u226560 and <89 years with a clinic follow\u2010up of at least 1 year and no diagnosis for\n AD<\/jats:styled-content>\n ,\n MM<\/jats:styled-content>\n or\n NMSC<\/jats:styled-content>\n at the time of the study entry. Data collected included age, gender, race and duration of follow\u2010up.\n MM<\/jats:styled-content>\n and\n NMSC<\/jats:styled-content>\n were detected by\n ICD<\/jats:styled-content>\n \u20109 codes and\n ICD<\/jats:styled-content>\n \u201010 codes. Incident diagnosis of\n AD<\/jats:styled-content>\n was also detected by\n ICD<\/jats:styled-content>\n \u20109 and\n ICD<\/jats:styled-content>\n \u201010 codes. Logistic regression analysis was utilized to obtain crude and adjusted odds ratios (\n OR<\/jats:styled-content>\n s).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Data for a total of 82 925 patients with known race and gender and were detected. After adjusting for confounding factors (race, gender, age, cerebrovascular disease, peripheral vascular disease and diabetes), there was a significant decreased risk of subsequent\n AD<\/jats:styled-content>\n in patients with\n MM<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n : 0.39; 95%\n CI<\/jats:styled-content>\n : 0.16\u20130.96;\n P<\/jats:italic>\n = 0.042) as well as in patients with\n BCC<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n : 0.18; 95%\n CI<\/jats:styled-content>\n : 0.08\u20130.45;\n P<\/jats:italic>\n < 0.0001) and for patients with\n SCC<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n : 0.08; 95%\n CI<\/jats:styled-content>\n : 0.01\u20130.56;\n P<\/jats:italic>\n = 0.013).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These findings add to the growing body of evidence for a decreased risk of\n AD<\/jats:styled-content>\n in patients with various cancers and highlight the need for ongoing research to elucidate both neurologic and biologic mechanisms that may underlie this apparent inverse association.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.14952","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T19:37:55Z","timestamp":1521920275000},"page":"1893-1896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Inverse association for diagnosis of Alzheimer's disease subsequent to both melanoma and non\u2010melanoma skin cancers in a large, urban, single\u2010centre, Midwestern\n US<\/scp>\n patient population"],"prefix":"10.1111","volume":"32","author":[{"given":"E.","family":"Ibler","sequence":"first","affiliation":[{"name":"Department of Dermatology Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.A.","family":"Orrell","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Serrano","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Majewski","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.A.","family":"Sable","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Thiede","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.E.","family":"Laumann","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.P.","family":"West","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Feinberg School of Medicine Chicago IL USA"},{"name":"Robert H. Lurie Comprehensive Cancer Center Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Nardone","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9497-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e1442"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c91873"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182941990"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171527"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-2-200601170-00004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2004.10.001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720509788486608"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63731-5"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.14952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.14952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.14952","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.14952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T03:53:59Z","timestamp":1694145239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.14952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,17]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/jdv.14952"],"URL":"https:\/\/doi.org\/10.1111\/jdv.14952","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,17]]},"assertion":[{"value":"2017-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}