{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:35:54Z","timestamp":1783485354739,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T00:00:00Z","timestamp":1526601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alopecia areata (<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>) is a hair follicle\u2010specific autoimmune disorder. Vitamin D deficiency has been associated with various autoimmune disorders for its immunomodulatory effects. However, in previous studies, there had been inconsistent association found between <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> and vitamin D deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To demonstrate the differences of the mean serum 25\u2010hydroxyvitamin D level and prevalence of vitamin D deficiency between <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients and non\u2010<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review and meta\u2010analysis of observational studies on <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> and serum vitamin D levels and\/or prevalence of vitamin D deficiency was performed searching <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>, Cochrane, Web of Science and Google Scholar databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 14 studies including a total of 1255 <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> subjects and 784 non\u2010<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> control were analysed. The mean serum 25\u2010hydroxyvitamin D level was significantly lower in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> subjects (\u22128.52\u00a0ng\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>; 95% confidential interval; \u22125.50 to \u221211.53). The AA subjects had higher odds of vitamin D deficiency (odds ratio of 3.89; 2.02 to 7.49, mean prevalence of 73.8%; 59.1 to 84.6%). However, it was difficult to find clear correlation between serum 25\u2010hydroxyvitamin D level and extent of hair loss in AA subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> subjects had lower serum 25\u2010hydroxyvitamin D level, and vitamin D deficiency was highly prevalent compared to non\u2010<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> controls. Hence, vitamin D deficiency should be assessed in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients. Furthermore, nutritional supplementation of vitamin D or topical vitamin D analogues can be considered for <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients with vitamin D deficiency. The limitation of this study is the highly heterogeneity of the included studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14987","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T06:43:41Z","timestamp":1523342621000},"page":"1214-1221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"32","author":[{"given":"S.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dermatology and Institute of Hair and Cosmetic Medicine Yonsei University Wonju College of Medicine Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Institute of Hair and Cosmetic Medicine Yonsei University Wonju College of 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