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Laser treatment was followed by <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content> application and illumination occurred 3\u00a0h later. This treatment was repeated after 2\u00a0weeks. An equivalence analysis was performed on the primary endpoint efficacy, while secondary endpoints pain, side\u2010effects and aesthetics were evaluated using paired samples tests. Patients were also asked for their preferred treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An excellent efficacy of 92.9% (<jats:styled-content style=\"fixed-case\">sBCC<\/jats:styled-content>, 100%; <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>, 80%) was found in both <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> after 12\u00a0months. Equivalence could not be established. Little pain was perceived in most patients during <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> illumination. <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> treatment in <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> was less painful, significantly during the second treatment (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.026). Side\u2010effects were mild to moderate with erythema being the most frequent immediate side\u2010effect, followed by oedema, crusting and burning sensation. Pigmentary changes occurred in 21% (<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>) to 29% (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>), and aesthetics were good to excellent in all patients. <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> did not significantly differ in side\u2010effects (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.219\u20131.000) or aesthetics (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.157\u20131.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results in this pilot study support the promising role of laser\u2010assisted <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>. Both treatment arms demonstrated the same efficacy as well as comparable side\u2010effects and aesthetics. <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> illumination was significantly less painful in the <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> group, suggesting a preference for <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>. The authors recommend further investigation with a larger sample size, a subgroup analysis between <jats:styled-content style=\"fixed-case\">sBCC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> and comparison of different treatment protocols before one technique could be preferred to another.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14989","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T06:43:48Z","timestamp":1523342628000},"page":"1897-1905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Laser\u2010assisted photodynamic therapy for superficial basal cell carcinoma and Bowen's disease: a randomized intrapatient comparison between a continuous and a fractional ablative <scp>CO<\/scp><sub>2<\/sub> laser mode"],"prefix":"10.1111","volume":"32","author":[{"given":"E.","family":"Genouw","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences Ghent University Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Verheire","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Ghent University Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ongenae","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ghent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"De Schepper","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ghent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Creytens","sequence":"additional","affiliation":[{"name":"Department of Pathology Ghent University Hospital Ghent Belgium"},{"name":"CRIG, Cancer Research Institute Ghent Ghent University Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Verhaeghe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ghent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Boone","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ghent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-78814-0_53"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1754-1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02088.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.10.006"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08666.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12766"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.01928.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.03.043"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12031"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2015.2570"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12148"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.03.048"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01093.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1853-z"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.008"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0516-9"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20606"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2011.3107"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13166"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12242"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13453"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12953"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12507"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10893.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12627"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2013.25.3.335"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22227"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e3182773ed2"},{"key":"e_1_2_5_30_1","unstructured":"IBM SPSS Statistics for Windows Version 22.0.IBM Corp. 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