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There is few summarized information about the role of inflammatory mediators, as interleukins, in vitiligo, so our aim was to present a systematic review of the role of interleukins in vitiligo, focusing on interleukins. In this review, we included all studies assessing interleukin levels in vitiligo patients conducted up to June 2017. Quality assessment of these studies was performed using the Newcastle\u2010Ottawa Scale (<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>). The interleukins mainly involved were <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017. The studies highlight the crucial role of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 in the onset and progression of the disease, and its synergistic action with <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201033. Dysregulated levels of the interleukins were also correlated with the stage of disease, the affected skin surface area, and indicated as the main factor for lymphocyte infiltration found in depigmented regions. These findings illustrate the growing need for new therapies targeting vitiligo and further research into the role of interleukins as an area of particular interest.<\/jats:p>","DOI":"10.1111\/jdv.15016","type":"journal-article","created":{"date-parts":[[2018,4,28]],"date-time":"2018-04-28T08:27:06Z","timestamp":1524904026000},"page":"2097-2111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The role of interleukins in vitiligo: a systematic review"],"prefix":"10.1111","volume":"32","author":[{"given":"I.A.","family":"Gomes","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas da Universidade Federal de Sergipe \u2013 UFS Campus Universit\u00e1rio \u201cProf. Alo\u00edsio de Campos\u201d S\u00e3o Crist\u00f3v\u00e3o SE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.O.","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"N\u00facleo de P\u00f3s\u2010Gradua\u00e7\u00e3o em Medicina da Universidade Federal de Sergipe \u2013 UFS Rua Cl\u00e1udio Batista S\/N Bairro Sanat\u00f3rio Aracaju SE Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.F.","family":"de Menezes","sequence":"additional","affiliation":[{"name":"N\u00facleo de P\u00f3s\u2010Gradua\u00e7\u00e3o em Medicina da Universidade Federal de Sergipe \u2013 UFS Rua Cl\u00e1udio Batista S\/N Bairro Sanat\u00f3rio Aracaju SE Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.M.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Departamento de Farm\u00e1cia Universidade Federal de Sergipe Campus Universit\u00e1rio \u201cProf. Alo\u00edsio de Campos\u201d S\u00e3o Crist\u00f3v\u00e3o SE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Shanmugam","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas da Universidade Federal de Sergipe \u2013 UFS Campus Universit\u00e1rio \u201cProf. Alo\u00edsio de Campos\u201d S\u00e3o Crist\u00f3v\u00e3o SE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"de Souza Siqueira Quintans","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia Universidade Federal de Sergipe Campus Universit\u00e1rio \u201cProf. Alo\u00edsio de Campos\u201d S\u00e3o Crist\u00f3v\u00e3o SE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.J.","family":"Quintans\u2010J\u00fanior","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia Universidade Federal de Sergipe Campus Universit\u00e1rio \u201cProf. Alo\u00edsio de Campos\u201d S\u00e3o Crist\u00f3v\u00e3o SE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.R.","family":"de Moura","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia Universidade Federal de Sergipe Campus Universit\u00e1rio \u201cProf. Alo\u00edsio de Campos\u201d S\u00e3o Crist\u00f3v\u00e3o SE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.D.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas da Universidade Federal de Sergipe \u2013 UFS Campus Universit\u00e1rio \u201cProf. Alo\u00edsio de Campos\u201d S\u00e3o Crist\u00f3v\u00e3o SE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"de Souza Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas da Universidade Federal de Sergipe \u2013 UFS Campus Universit\u00e1rio \u201cProf. Alo\u00edsio de Campos\u201d S\u00e3o Crist\u00f3v\u00e3o SE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.12.003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2016.1215434"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.10.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.12.006"},{"key":"e_1_2_6_6_1","unstructured":"Arthur Rook.Rook's Textbook of Dermatology [Internet]. 9th ed. 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