{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:25:44Z","timestamp":1760016344392},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,5,27]],"date-time":"2018-05-27T00:00:00Z","timestamp":1527379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Trachyonychia can be refractory to conventional treatments including topical, intralesional or systemic corticosteroids, as well as cyclosporine and retinoids. Therefore, new treatment options are needed for recalcitrant trachyonychia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy and safety of oral alitretinoin for idiopathic recalcitrant trachyonychia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 21 adult patients with 210 nails affected by idiopathic recalcitrant trachyonychia were evaluated in this open\u2010label prospective study. All patients took 30 mg of alitretinoin daily for at least 3 months. Clinical outcomes were assessed using the Physician Global Assessment (<jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>) scale proposed by Park <jats:italic>et al<\/jats:italic>. (degree of roughness: 0, clear; 1, mild; 2, moderate; 3, marked; 4, severe) at baseline and 1, 3 and 6 months after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 1, 3 and 6 months of treatment, 74.3% (123\/210), 98.1% (206\/210) and 99.2% (119\/120) of nails showed clinical improvement, respectively; 0% (0\/210), 22.9% (48\/210) and 69.2% (83\/120) were completely free from nail abnormalities. The mean <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content> score at baseline was 3.4, decreasing significantly to 2.7, 1.3 and 0.7 at 1, 3 and 6 months following treatment, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>A small number of participants and lack of a control group were limitations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For the first time, this study evaluated the efficacy and safety of oral alitretinoin for idiopathic recalcitrant trachyonychia in adults. The results suggest that oral alitretinoin can be a good treatment option for adult patients with recalcitrant trachyonychia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15024","type":"journal-article","created":{"date-parts":[[2018,4,28]],"date-time":"2018-04-28T08:05:38Z","timestamp":1524902738000},"page":"1810-1814","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Alitretinoin can be a good treatment option for idiopathic recalcitrant trachyonychia in adults: an open\u2010label study"],"prefix":"10.1111","volume":"32","author":[{"given":"K.","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine Pusan National University Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.\u2010W.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Pusan National University Busan 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