{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:18:43Z","timestamp":1790255923558,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pierre Fabre Dermo-Cosmetique, DUCRAY Laboratoires Dermatologiques, Lavaur, France"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our main objective was to compare <jats:italic>Cutibacterium acnes<\/jats:italic> (<jats:italic>C.\u00a0acnes<\/jats:italic>) skin colonisation in patients with mild to moderate acne versus healthy controls and secondly, to evaluate a Myrtacine<jats:sup>\u00ae<\/jats:sup>\u2010based cream on <jats:italic>C.\u00a0acnes<\/jats:italic> total population and antibioresistant <jats:italic>Cutibacteria<\/jats:italic> in patients with acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 60 acne patients (Global Acne Severity Scale, <jats:styled-content style=\"fixed-case\">GEA<\/jats:styled-content> grades 2\u20133), of mean age 20 [15\u201330] years and in 24 age\u2010 and sex\u2010 matched healthy controls, forehead strips samplings were performed for microbiological analysis of comedones by colony forming unit (<jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content>) counts of global <jats:italic>C.\u00a0acnes<\/jats:italic> and erythromycin (EryR) or clindamycin\u2010resistant (ClnR) populations of <jats:italic>Cutibacterium<\/jats:italic> and determination of phylotypes by <jats:styled-content style=\"fixed-case\">MALTI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>. Clinical evaluations of acne patients (<jats:styled-content style=\"fixed-case\">GEA<\/jats:styled-content>, lesion count, porphyrin fluorescence) were performed at baseline and after 56\u00a0days of twice\u2010daily application of a Myrtacine<jats:sup>\u00ae<\/jats:sup>\u2010based cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We first showed (i) high and similar levels of <jats:italic>C.\u00a0acnes<\/jats:italic> colonisation in superficial pilosebaceous follicles and detection of EryR and ClnR strains in both acne and control groups; (ii) different repartition of phylotypes in acne patients versus healthy control, with a predominance of phylotype <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> in acne patients and a link between phylotype <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> and erythromycin resistance. Besides, after treatment with the Myrtacine<jats:sup>\u00ae<\/jats:sup>\u2010based cream in acne patients, there was no change in <jats:italic>C.\u00a0acnes<\/jats:italic> total load, but a significant decrease of EryR <jats:italic>Cutibacteria,<\/jats:italic> reduced porphyrin production by <jats:italic>C.\u00a0acnes,<\/jats:italic> a decrease in acne severity (<jats:styled-content style=\"fixed-case\">GEA<\/jats:styled-content>), associated with reduced retentional and inflammatory lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>Cutibacterium acnes<\/jats:italic> colonisation was not significantly different in acne versus control groups. Phylotype <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> was predominant in acne patient and in EryR <jats:italic>C.\u00a0acnes<\/jats:italic>. A Myrtacine<jats:sup>\u00ae<\/jats:sup>\u2010based cream significantly reduced the level of EryR <jats:italic>Cutibacteria in\u00a0vivo<\/jats:italic> and improved acne lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15042","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T16:54:41Z","timestamp":1528822481000},"page":"15-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Characterisation of <i>Cutibacterium acnes<\/i> phylotypes in acne and <i>in\u00a0vivo<\/i> exploratory evaluation of Myrtacine<sup>\u00ae<\/sup>"],"prefix":"10.1111","volume":"32","author":[{"given":"S.","family":"P\u00e9castaings","sequence":"first","affiliation":[{"name":"Laboratoire de G\u00e9nie Chimique UMR 5503 Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier CNRS INPT Toulouse Cedex 9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Roques","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9nie Chimique UMR 5503 Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier CNRS INPT Toulouse Cedex 9 France"},{"name":"Fonderephar  Faculty of Pharmacy Toulouse Cedex 9 France"},{"name":"CHU Toulouse H\u00f4pital Purpan, Service de Bact\u00e9riologie\u2010Hygi\u00e8ne Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th.","family":"Nocera","sequence":"additional","affiliation":[{"name":"Clinical Skin Research Center Pierre Fabre Dermo\u2010Cosmetique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Peraud","sequence":"additional","affiliation":[{"name":"Clinical Skin Research Center Pierre Fabre Dermo\u2010Cosmetique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Mengeaud","sequence":"additional","affiliation":[{"name":"Laboratoires Dermatologiques Ducray Pierre Fabre Dermo\u2010Cosm\u00e9tique Cauquillous Lavaur France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Khammari","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Nantes CIC 1413 CRCINA University Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Dr\u00e9no","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Nantes CIC 1413 CRCINA University Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39491"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14967"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.037"},{"key":"e_1_2_6_5_1","unstructured":"S3\u2010Guideline for the Treatment of Acne (Update 2016) Developed by the Guideline Subcommittee \u201cAcne\u201d of the European Dermatology Forum."},{"key":"e_1_2_6_6_1","unstructured":"Acne management: Local and systemic treatment of acne Guidelines of the French Dermatology Society 10 June2015 Available at:http:\/\/www.sfdermato.org\/media\/pdf\/recommandation\/label-recommandations-acne-post-college-54ac60356d1b9584a71ccaac92cf3724.pdf last accessed: December 2017."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04690.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.10.008"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2007.02.001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2015.11.016"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03685.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90497-1"},{"key":"e_1_2_6_13_1","first-page":"136","article-title":"ECLA grading: a system of acne classification for every day dermatological practice","volume":"126","author":"Dreno B","year":"1999","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.24.4.638-644.1972"},{"key":"e_1_2_6_15_1","unstructured":"The European committee on Antimicrobial Susceptibility Testing.Breakpoint tables for interpretation of MICs and zone diameters. 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