{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:19:50Z","timestamp":1792642790839,"version":"4.5.0"},"reference-count":76,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pierre Fabre Dermo-Cosmetique DUCRAY Laboratoires Dermatologiques, Lavaur, France"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>While the commensal bacterium <jats:italic>Propionibacterium acnes<\/jats:italic> (<jats:italic>P.\u00a0acnes<\/jats:italic>) is involved in the maintenance of a healthy skin, it can also act as an opportunistic pathogen in acne vulgaris. The latest findings on <jats:italic>P.\u00a0acnes<\/jats:italic> shed light on the critical role of a tight equilibrium between members of its phylotypes and within the skin microbiota in the development of this skin disease. Indeed, contrary to what was previously thought, proliferation of <jats:italic>P.\u00a0acnes<\/jats:italic> is not the trigger of acne as patients with acne do not harbour more <jats:italic>P.\u00a0acnes<\/jats:italic> in follicles than normal individuals. Instead, the loss of the skin microbial diversity together with the activation of the innate immunity might lead to this chronic inflammatory condition. This review provides results of the most recent biochemical and genomic investigations that led to the new taxonomic classification of <jats:italic>P.\u00a0acnes<\/jats:italic> renamed <jats:italic>Cutibacterium acnes<\/jats:italic> (<jats:italic>C.\u00a0acnes<\/jats:italic>), and to the better characterisation of its phylogenetic cluster groups. Moreover, the latest data on the role of <jats:italic>C.\u00a0acnes<\/jats:italic> and its different phylotypes in acne are presented, providing an overview of the factors that could participate in the virulence and in the antimicrobial resistance of acne\u2010associated strains. Overall, this emerging key information offers new perspectives in the treatment of acne, with future innovative strategies focusing on <jats:italic>C.\u00a0acnes<\/jats:italic> biofilms and\/or on its acne\u2010associated phylotypes.<\/jats:p>","DOI":"10.1111\/jdv.15043","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T12:54:41Z","timestamp":1528808081000},"page":"5-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":550,"title":["<i>Cutibacterium acnes<\/i> (<i>Propionibacterium acnes<\/i>) and acne vulgaris: a brief look at the latest updates"],"prefix":"10.1111","volume":"32","author":[{"given":"B.","family":"Dr\u00e9no","sequence":"first","affiliation":[{"name":"Department of Dermatology CIC 1413 CRCINA Inserm 1232 CHU Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"P\u00e9castaings","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9nie Chimique UMR 5503, Faculty of Pharmacy Universit\u00e9 de Toulouse Universit\u00e9 Paul Sabatier Toulouse Cedex 9 France"},{"name":"CHU Toulouse H\u00f4pital Purpan Service de Bact\u00e9riologie\u2010Hygi\u00e8ne Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Corvec","sequence":"additional","affiliation":[{"name":"Department of Bacteriology CRCINA Inserm 1232 CHU Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Veraldi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano I.R.C.C.S. 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