{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:18:03Z","timestamp":1778602683249,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T00:00:00Z","timestamp":1527465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Kaposi's sarcoma (<jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>) is a rare endothelial neoplasm caused by the human herpesvirus 8 (<jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20108). Its risk is increased in immunocompromised patients, including those undergoing immunosuppressive therapy for autoimmune bullous diseases. Conversely,<jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20108 infection has been hypothesized to be a triggering factor of bullous diseases, especially pemphigus. Given the fact that both<jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>and autoimmune bullous diseases have a low incidence in the general population, it could be expected that the association between these disorders would be exceptional.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the frequency of bullous diseases in a large cohort of non\u2010<jats:styled-content style=\"fixed-case\">HIV KS<\/jats:styled-content>patients and to describe our experience concerning the clinical features, natural history and treatment options in this setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of all patients with non\u2010<jats:styled-content style=\"fixed-case\">HIV KS<\/jats:styled-content>in association with bullous disease followed at our department between 1990 and 2016. Medical records were reviewed for demographics, medical history, clinical characteristics and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1362 patients with classic or iatrogenic<jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>, 14 (1.03%) also suffered from bullous disease. The mean age at diagnosis of both disorders was 85.8 years with a male\/female ratio of 9 : 5. Among these 14 cases, nine (0.66%) were associated with bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>), three (0.22%) with localized<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>and two (0.15%) with pemphigus vulgaris. Seven had developed a bullous disease after being diagnosed with<jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>, while in the remaining seven cases,<jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>developed after the onset of bullous disease. As expected,<jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>worsened when corticosteroids were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bullous diseases seem to be more frequent among patients with<jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>, supporting the hypothesis that<jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20108 may be involved in their pathogenesis. Therapeutic management of these cases should take into account<jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>\u2010inducing potential of corticosteroids.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15051","type":"journal-article","created":{"date-parts":[[2018,5,5]],"date-time":"2018-05-05T10:54:17Z","timestamp":1525517657000},"page":"1777-1783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Autoimmune bullous diseases in non\u2010<scp>HIV<\/scp>Kaposi's sarcoma: a retrospective study in a large cohort of patients"],"prefix":"10.1111","volume":"32","author":[{"given":"A.","family":"Tourlaki","sequence":"first","affiliation":[{"name":"Dipartimento di Fisiopatologia Medico\u2010Chirurgica e dei Trapianti Unit\u00e0 Operativa di Dermatologia IRCCS Fondazione Ca\u2019 Granda Ospedale Maggiore Policlinico Universit\u00e0 degli Studi di Milano Milan 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