{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:08:09Z","timestamp":1790453289239,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ALERD (Association Lorraine d'Etudes et de Recherches en Dermatologie)"},{"name":"Department of Toxicology of Le Havre Hospital"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Silver\u2010containing dressings are considered to be safe even though there have been some reports of complications, including argyria and various organ system dysfunctions. Despite the widespread use of silver dressings, little research has been done regarding the absorption and toxicity of silver.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to study the systemic absorption of silver in patients with chronic inflammatory wounds and to determine associated factors of systemic silver absorption and evaluated its association with silver toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and method<\/jats:title>\n                    <jats:p>Prospective, longitudinal, observational, multicentre, open\u2010label pilot study. Patients from the Dermatology Departments of Lorraine (France) with the following inclusion criteria: (i) a chronic wound of more than 6\u00a0weeks and (ii) an ulcer needing silver\u2010containing dressing were included. Before and after 28\u00a0days of treatment, clinical characteristics of the wound were recorded; hemogram, hepatic and renal functions, albumin sera and serum silver level were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Half of the cases displayed raised levels of silver after 1\u00a0month of treatment. Predictive factors for systemic silver absorption were wound area, anaemia and malnutrition with anaemia and malnutrition confirmed on multivariate analysis. Wound vascularization may also play a role, as a higher absorption was observed in cases of wound granulation without arterial components. No toxicity was detected. This work has also emphasized the slow elimination of silver from the body.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both long\u2010term application and iterative treatments with silver dressings should be discouraged, especially in the elderly, who often suffer from malnutrition and anaemia to avoid potential cumulative toxicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.15055","type":"journal-article","created":{"date-parts":[[2018,5,6]],"date-time":"2018-05-06T05:55:58Z","timestamp":1525586158000},"page":"2295-2299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Silver absorption and toxicity evaluation of silver wound dressings in 40 patients with chronic wounds"],"prefix":"10.1111","volume":"32","author":[{"given":"C.","family":"Brouillard","sequence":"first","affiliation":[{"name":"Department of Dermatology Nancy University Hospital Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010C.","family":"Bursztejn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nancy University Hospital Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Latarche","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Nancy University Hospital Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010F.","family":"Cuny","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nancy University Hospital Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Truchetet","sequence":"additional","affiliation":[{"name":"Department of Dermatology Metz\u2010Thionville Regional Hospital Thionville France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010P.","family":"Goull\u00e9","sequence":"additional","affiliation":[{"name":"Department of Toxicology Le Havre Hospital Le Havre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010L.","family":"Schmutz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nancy University Hospital Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2002.11.4.26389"},{"key":"e_1_2_7_3_1","first-page":"CD011038","article-title":"Topical antimicrobial agents for treating foot ulcers in people with diabetes","volume":"6","author":"Dumville JC","year":"2017","journal-title":"Cochrane Database Sys 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