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One of the earliest and most common symptoms of\n                    <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>\n                    is pruritus, which affects up to 88% of patients. The severity of pruritus can range from mild to very debilitating, producing tremendous discomfort and a significant decrease in quality of life. Patients with advanced disease, in particular, may experience a more chronic, intractable pruritus. However, the underlying mechanism of pruritus in\n                    <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>\n                    remains unknown. Conventional antipruritic agents, such as antihistamines, gamma\u2010aminobutyric acid analogs and antidepressants, are only partially effective in relieving symptoms, suggesting a more complex, unique pathophysiology. In this review, we summarize the current research on cytokines and peripheral mediators implicated in pruritus in\n                    <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/jdv.15075","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T17:00:26Z","timestamp":1526662826000},"page":"1652-1656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Inflammatory cytokines and peripheral mediators in the pathophysiology of pruritus in cutaneous T\u2010cell lymphoma"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1610-5785","authenticated-orcid":false,"given":"D.J.","family":"Lewis","sequence":"first","affiliation":[{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center Houston TX USA"},{"name":"School of Medicine Baylor 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