{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T01:13:56Z","timestamp":1776474836677,"version":"3.51.2"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have compared the efficacy of switching to adalimumab in the real\u2010life setting in plaque psoriasis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of adalimumab in psoriasis patients previously treated with other biologics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this multicentre study, psoriasis patients (<jats:italic>N<\/jats:italic>\u00a0=\u00a0262) treated with an anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha agent, ustekinumab or na\u00efve to biologics then switched to adalimumab were included. Disease severity was assessed by the Psoriasis Area and Severity Index (<jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content>) at baseline and after 3, 6, 12, 24 and 36\u00a0months. The association between clinical risk factors and achievement of <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> response was evaluated by logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adalimumab treatment resulted in a decrease in <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> (15.1\u00a0\u00b1\u00a06.2 at baseline vs. 2.7\u00a0\u00b1\u00a04.8 at 6\u00a0months, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), regardless of previous biologic treatment. Furthermore, adalimumab allowed 92.5%, 79% and 56% of patients to achieve <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> response (<jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> 50, 75 and 90, respectively) and complete remission (<jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> 100 response) in 48.4% of patients, by 6\u00a0months and maintained over 3\u00a0years, independent of prior biologic treatment. The absence of metabolic syndrome, dyslipidemia, hypertension and lower <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> and lower age at baseline was associated with achievement of <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> response at 3, 6 and 12\u00a0months, whereas at later time points (24 and 36\u00a0months), <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> 90 and <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> 100 response was associated with diagnosis of psoriasis\/psoriatic arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adalimumab was effective at reducing <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> score over 3\u00a0years, irrespective of whether patients were biologic na\u00efve or previously treated with a <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha or <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012\/23 inhibitor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15077","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T21:01:52Z","timestamp":1526677312000},"page":"1737-1744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Psoriasis Area and Severity Index response in moderate\u2010severe psoriatic patients switched to adalimumab: results from the <scp>OPPSA<\/scp> study"],"prefix":"10.1111","volume":"32","author":[{"given":"M.","family":"Talamonti","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Rome \u2018Tor Vergata\u2019 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Galluzzo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Rome \u2018Tor Vergata\u2019 Rome 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