{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:42:03Z","timestamp":1787496123606,"version":"build-2736575974"},"reference-count":9,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T00:00:00Z","timestamp":1528329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Teledermatology (\n TD<\/jats:styled-content>\n ) provides efficient care for skin cancer patients.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To compare the clinical effectiveness of imiquimod 5% for the treatment of\n AK<\/jats:styled-content>\n with in\u2010person care and through\n TD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Longitudinal prospective controlled study including patients with single\n AK<\/jats:styled-content>\n diagnosed and treated at face\u2010to\u2010face visits (\n FTF<\/jats:styled-content>\n group) or through teledermatology (\n TD<\/jats:styled-content>\n group) with imiquimod 5% cream. The main outcome measures assessed were the complete and global response percentage (\n CR<\/jats:styled-content>\n and\n GR<\/jats:styled-content>\n ) under per\u2010protocol (\n PP<\/jats:styled-content>\n ) and intention\u2010to\u2010treat (\n ITT<\/jats:styled-content>\n ) analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 157 patients were enrolled (\n FTF<\/jats:styled-content>\n = 75,\n TD<\/jats:styled-content>\n = 82).\n PP<\/jats:styled-content>\n analysis showed\n CR<\/jats:styled-content>\n in 66.7% of\n FTF<\/jats:styled-content>\n patients and 65.6% in\n TD<\/jats:styled-content>\n patients (\n P<\/jats:italic>\n > 0.05). The\n ITT<\/jats:styled-content>\n yielded\n CR<\/jats:styled-content>\n in 64.0% and 51.2% in\n FTF<\/jats:styled-content>\n visits and\n TD<\/jats:styled-content>\n , respectively (\n P<\/jats:italic>\n = 0.073). The analysis showed an advantage of\n FTF<\/jats:styled-content>\n care against\n TD<\/jats:styled-content>\n in achieving\n GR<\/jats:styled-content>\n (84.0% vs. 70.7%;\n P<\/jats:italic>\n = 0.036). Facial location and local adverse reactions were the only explanatory factors of complete response in the\n ITT<\/jats:styled-content>\n approach. Treatment completion was found in 90.7% and 72.0% in the\n FTF<\/jats:styled-content>\n and\n TD<\/jats:styled-content>\n groups, respectively (\n P<\/jats:italic>\n = 0.004).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Improvements in patient counselling at the primary care centre are needed before the implementation of\n TD<\/jats:styled-content>\n as a routine methodology for the management of\n AK<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.15085","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T12:09:29Z","timestamp":1527163769000},"page":"2149-2152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Teledermatology\u2010driven topical therapy of actinic keratosis: a comparative study of clinical effectiveness and compliance"],"prefix":"10.1111","volume":"32","author":[{"given":"L.","family":"Ferr\u00e1ndiz","sequence":"first","affiliation":[{"name":"Dermatology Unit & Teledermatology Network Hospital Universitario Virgen Macarena Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Morales\u2010Conde","sequence":"additional","affiliation":[{"name":"Dermatology Unit & Teledermatology Network Hospital Universitario Virgen Macarena Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fern\u00e1ndez\u2010Orland","sequence":"additional","affiliation":[{"name":"Dermatology Unit & Teledermatology Network Hospital Universitario Virgen Macarena Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.J.","family":"Mart\u00edn\u2010Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Dermatology Unit & Teledermatology Network Hospital Universitario Virgen Macarena Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Raya\u2010Maldonado","sequence":"additional","affiliation":[{"name":"Dermatology Unit & Teledermatology Network Hospital Universitario Virgen Macarena Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Toledo\u2010Pastrana","sequence":"additional","affiliation":[{"name":"Dermatology Unit & Teledermatology Network Hospital Universitario Virgen Macarena Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Moreno\u2010Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Dermatology Unit & Teledermatology Network Hospital Universitario Virgen Macarena Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14341"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0283-z"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2016.05.016"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2013.11.013"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13180"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.778"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.10.041"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700264"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.0525"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.15085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:15:40Z","timestamp":1694736940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.15085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,7]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/jdv.15085"],"URL":"https:\/\/doi.org\/10.1111\/jdv.15085","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,7]]},"assertion":[{"value":"2018-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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