{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:33:10Z","timestamp":1778862790266,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T00:00:00Z","timestamp":1529971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Topical methyl aminolevulinate photodynamic therapy (<jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>) with 3 h incubation is recommended as a field directed treatment. Skin pretreatment with ablative <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> fractional laser (<jats:styled-content style=\"fixed-case\">AFXL<\/jats:styled-content>) prior to <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> enhances drug penetration and could minimize incubation time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate and compare the safety and the preventive effect in the development of new non\u2010melanocytic skin cancers (<jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>s) of <jats:styled-content style=\"fixed-case\">AFXL<\/jats:styled-content>\u2010assisted <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> with 1\u2010h incubation with that of conventional <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> in patients with clinical and histological signs of field cancerization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010two patients with two mirror cancerized areas of face or scalp were randomized to field treatment with 1\u2010h incubation <jats:styled-content style=\"fixed-case\">AFXL<\/jats:styled-content>\u2010assisted <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> or conventional <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CPDT<\/jats:styled-content>). All patients underwent two treatment sessions 1 week apart. Irradiation was performed using a red light\u2010emitting diode lamp at 37 J\/cm<jats:sup>2<\/jats:sup>. Patients were followed up at 3, 6, 9 and 12 months for the evaluation of development of new <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>s lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients completed the study. There was no statistically significant difference with respect to the total number of new actinic keratoses at any point of follow\u2010up as well as to the mean time of occurrence of new lesions between treatment fields. Both treatment regimens were safe and well tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ablative <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> fractional laser pretreatment may be considered as an option for reducing photosensitizer occlusion time while providing the same preventative efficacy as <jats:styled-content style=\"fixed-case\">CPDT<\/jats:styled-content> in patients with field\u2010cancerized skin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15109","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T06:56:45Z","timestamp":1528181805000},"page":"79-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Short incubation fractional CO<sub>2<\/sub> laser\u2010assisted photodynamic therapy vs. conventional photodynamic therapy in field\u2010cancerized skin: 12\u2010month follow\u2010up results 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