{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:48:05Z","timestamp":1791917285459,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nail unit melanoma (<jats:styled-content style=\"fixed-case\">NUM<\/jats:styled-content>) is a rare melanoma variant, usually associated with a poor prognosis because of a delayed diagnosis. Few data are available concerning the management and long\u2010term outcome of in situ <jats:styled-content style=\"fixed-case\">NUM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To use a large cohort to provide comprehensive patient data and long\u2010term follow\u2010up information. This will serve to investigate distinctive epidemiological, clinical and histological features of in situ <jats:styled-content style=\"fixed-case\">NUM<\/jats:styled-content>. To report treatment modalities, assess conservative surgery and evaluate its long\u2010term safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with confirmed diagnosis of in situ <jats:styled-content style=\"fixed-case\">NUM<\/jats:styled-content> were retrospectively reviewed. Demographics, clinical presentation, therapeutic data and follow\u2010up were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010three cases of in situ <jats:styled-content style=\"fixed-case\">NUM<\/jats:styled-content> were identified as follows: 44 were women (70%), with a mean age of 51 years. The mean duration of symptoms prior to consultation was 4.3 years [range 3 months\u201328 years]. Clinically, with 58 cases, i.e. (92%) longitudinal melanonychia was the most common clinical presentation. The thumb was the most affected digit, being afflicted in 28 cases: 44%. Medical history found a widening and\/or recent darkening of the melanonychia in 46 cases (82%). The treatment consisted of, respectively, 56 En bloc excisions of the nail apparatus 89% of the patients we studied, and seven amputations of the distal phalanx. During the follow\u2010up period (mean: 10 years), two patients presented in situ recurrences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The recognition of a <jats:styled-content style=\"fixed-case\">NUM<\/jats:styled-content> at an in situ stage allows early treatment and curing of this tumour. At this early stage, a \u2018functional surgery\u2019 is a rational approach with an excellent oncologic safety.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15124","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T16:44:32Z","timestamp":1528821872000},"page":"2300-2306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["In situ nail unit melanoma: epidemiological and clinic\u2010pathologic features with conservative treatment and long\u2010term follow\u2010up"],"prefix":"10.1111","volume":"32","author":[{"given":"S.","family":"Goettmann","sequence":"first","affiliation":[{"name":"Dermatology Dermatology Office Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Moulonguet","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Pathology Office Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Zaraa","sequence":"additional","affiliation":[{"name":"Dermatology Department Bichat\u2010Claude Bernard Hospital Paris 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