{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:10:16Z","timestamp":1787015416635,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006451","name":"Hospices Civils de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006451","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vulvar melanosis can occasionally be clinically challenging by mimicking an early melanoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To report our experience of initial evaluation and follow\u2010up in this peculiar subset of vulvar melanosis using reflectance confocal microscopy (\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      )\n                      <jats:bold>.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively evaluated 18 consecutive cases referred for atypical vulvar pigmentation or for which melanoma was considered and that underwent both RCM examination and histopathological assessment. In 13 cases with available dermoscopic pictures,\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      classification was compared to dermoscopic diagnosis, and in all cases, the density of melanocytes was evaluated on biopsies using MelanA immunostaining.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 18 atypical pigmented lesions, 17 vulvar melanosis and one melanoma were histologically determined.\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      concluded a benign vulvar melanosis in 10 of 17 cases, whereas dermoscopy did so in three of 12 cases.\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      identified the only early malignant lentiginous melanoma. In several cases of vulvar melanosis,\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      could identify foci of melanocytic hyperplasia in an otherwise benign pattern.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In this clinically and dermoscopically challenging subset of vulvar pigmentations,\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      appears relevant for initial extensive evaluation, especially to target initial biopsy sampling, and to perform non\u2010invasive monitoring of foci of melanocytic hyperplasia.\n                    <\/jats:p>\n                  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