{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:40:34Z","timestamp":1790422834988,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T00:00:00Z","timestamp":1532995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sarcoidosis, characterized by epithelioid granulomas, is considered to be caused by a complex interplay between genetics and environmental agents. It has been hypothesized that exogenous inorganic particles as crystalline silica could be a causal or adjuvant agent in sarcoidosis onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the location, frequency and physicochemical characteristics of foreign materials and mineral tissue deposits in the granulomatous area of cutaneous sarcoidosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Skin biopsies (<jats:italic>n<\/jats:italic> = 14) from patients diagnosed with cutaneous sarcoidosis (mean age 43 years; 11 patients with extracutaneous involvement) were investigated using polarized light examination (<jats:styled-content style=\"fixed-case\">PLE<\/jats:styled-content>), \u03bcFourier Transform Infra\u2010Red (\u03bc<jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) spectroscopy and Field Emission Scanning Electron Microscopy coupled with Energy Dispersive X\u2010ray Spectroscopy (<jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SEM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EDX<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Combined <jats:styled-content style=\"fixed-case\">PLE<\/jats:styled-content>, \u03bc<jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SEM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EDX<\/jats:styled-content> analysis allowed to characterize mineral deposits in 7\/14 biopsies (50%). It identified crystalline silica (SiO<jats:sub>2<\/jats:sub>) inside granulomas in three biopsies and calcite (Ca<jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>3<\/jats:sub>) at their periphery in 4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study emphasizes the need of using combined methods for assessment of mineral deposits in granulomatous diseases. According to the location and characteristics of deposits, we can hypothesize that SiO<jats:sub>2<\/jats:sub> particles contribute to the granuloma formation, whereas Ca<jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>3<\/jats:sub> deposits are related to the granuloma biology. However, the significance of the association between SiO<jats:sub>2<\/jats:sub> deposits and sarcoidosis is still disputed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15167","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T21:04:30Z","timestamp":1530738270000},"page":"198-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Physicochemical characterization of inorganic deposits associated with granulomas in cutaneous sarcoidosis"],"prefix":"10.1111","volume":"33","author":[{"given":"H.","family":"Colboc","sequence":"first","affiliation":[{"name":"Dermatologie H\u00f4pital Rothschild, AP\u2010HP Paris France"},{"name":"Sorbonne Universit\u00e9, UPMC Universit\u00e9 Paris 06 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Moguelet","sequence":"additional","affiliation":[{"name":"Anatomie et Cytologie Pathologiques H\u00f4pital Tenon, 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