{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T04:34:45Z","timestamp":1717907685435},"reference-count":78,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T00:00:00Z","timestamp":1535414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Due to the high relapse rates and the rise of predisposing factors, the need for curing onychomycosis is paramount. To effectively address onychomycosis, the definition of cure used in a clinical setting should be agreed upon and applied homogeneously across therapies (e.g. oral, topical and laser treatments). In order to determine what is or what should be used to define cure in a clinical setting, a literature search was conducted to identify methods used to evaluate treatment success. The limitations, strengths, prevalence and utility of each outcome measure were investigated. Seven ways to measure treatment success were identified; mycological cure, patient\/investigator assessments, complete cure, quality of life instruments, severity indexes, clinical cure and temporary clearance. Despite its shortcomings, mycological cure is the most objective and consistent outcome measure used across onychomycosis studies. It is suggested that diagnostic goals of onychomycosis should be used to define cure in a clinical setting. Modifications to outcome measures such as incorporating molecular\u2010based techniques could be a future avenue to explore.<\/jats:p>","DOI":"10.1111\/jdv.15181","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T16:53:55Z","timestamp":1531500835000},"page":"281-287","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A practical application of onychomycosis cure \u2013 combining patient, physician and regulatory body perspectives"],"prefix":"10.1111","volume":"33","author":[{"given":"A.K.","family":"Gupta","sequence":"first","affiliation":[{"name":"Divison of Dermatology Department of Medicine University of Toronto School of Medicine Toronto ON Canada"},{"name":"Mediprobe Research Inc. London ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.G.","family":"Versteeg","sequence":"additional","affiliation":[{"name":"Mediprobe Research Inc. London ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.H.","family":"Shear","sequence":"additional","affiliation":[{"name":"Department of Medicine (Dermatology, Clinical Pharmacology and Toxicology) Department of Pharmacology Sunnybrook Health Science Centre and the University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.7547\/0003-0538-104.4.330"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12537"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13677"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12533"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-016-0014-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12448"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12986"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.12.1551"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425240802497218"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017990"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.3.353"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13402"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02464.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2016.1161156"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14212"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0759-8-15"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00449429"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008986826756"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70199-9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603283341306"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03520080061045"},{"issue":"1","key":"e_1_2_7_23_1","first-page":"6","article-title":"The Scoring Clinical Index for Onychomycosis (SCIO index)","volume":"7","author":"Sergeev AY","year":"2002","journal-title":"Skin Ther Lett"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.267"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630701243418"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13798"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.04.054"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368348"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2007.00310.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.002"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13842"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12292_suppl"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7010.919"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70486-4"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155599750011020"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70111-7"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.10.013"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2012.02215.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7190.1031"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.00008.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb06088.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03247.x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630500504713"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.0785"},{"key":"e_1_2_7_45_1","unstructured":"US Food and Drug Administration.Medical Devices and Clinical Trial Design for the Treatment or Improvement in the Appearance of Fungally\u2010Infected Nails \u2010 Draft Guidance for Industry and FDA Staff [Internet].2015[cited 2017 May 22]. Available from:http:\/\/www.fda.gov\/downloads\/MedicalDevices\/DeviceRegulationandGuidance\/GuidanceDocuments\/UCM431312.pdf"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475417733461"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12251"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475417716362"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.04.010"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-016-0038-z"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.7547\/15-136"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70492-X"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1997.tb00505.x"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630050517658"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.109071"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017905"},{"key":"e_1_2_7_57_1","first-page":"60","article-title":"Onychomycosis: current and future therapies","volume":"93","author":"Lipner S","year":"2014","journal-title":"Cutis"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01728.x"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690200057011"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03164.x"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1998.tb00330.x"},{"key":"e_1_2_7_62_1","first-page":"34","article-title":"Topical treatment for onychomycosis: is it more effective than the clinical data suggests?","volume":"9","author":"Elewski BE","year":"2016","journal-title":"J Clin Aesthetic Dermatol"},{"key":"e_1_2_7_63_1","first-page":"1","article-title":"A retrospective chart review of the clinical efficacy of Nd:YAG 1064\u2010nm laser for toenail onychomycosis","volume":"20","author":"Gupta AK","year":"2014","journal-title":"J Dermatol Treat"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.7547\/1020169"},{"key":"e_1_2_7_65_1","unstructured":"Stanford University.Treatment of Onychomycosis Using a 0.65 Millisecond Pulsed Nd:YAG 1064 nm Laser \u2013 Full Text View \u2013 ClinicalTrials.gov [Internet].2012[cited 2017 Oct 3]. Available from:http:\/\/clinicaltrials.gov\/show\/NCT01666002"},{"key":"e_1_2_7_66_1","first-page":"71610M1","article-title":"Laser treatment for toenail fungus","volume":"7161","author":"Harris DM","year":"2009","journal-title":"Proc SPIE"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000189"},{"key":"e_1_2_7_68_1","unstructured":"Erchonia Corporation.Study of the Use of Low Level Laser Light Therapy to Treat Toenail Fungus [Internet]. ClinicalTrials.gov.2012[cited 2017 Oct 3]. Available from:http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01534689"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2007.01422.x"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.4190"},{"key":"e_1_2_7_71_1","unstructured":"WilliamsR MikailovA CohenJ CanalesA MostaghlmiA.The Clinical Diagnosis of Onychomycosis by Physicians: Is a Confirmatory Test Necessary? [Internet]. American Academy of Dermatology 73rd Annual Meeting;2015Mar [cited 2017 Oct 3]; San Francisco CA. Available from:https:\/\/www.aad.org\/eposters\/Submissions\/getFile.aspx?id=1823&type=sub"},{"key":"e_1_2_7_72_1","first-page":"626","article-title":"Onychomycosis: does cure equate to treatment success?","volume":"15","author":"Elewski BE","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12072"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70047-2"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03362.x"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-4-50"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026429012353"},{"key":"e_1_2_7_78_1","first-page":"601","article-title":"Comparison of two topical preparations for the treatment of onychomycosis: Melaleuca alternifolia (tea tree) oil and clotrimazole","volume":"38","author":"Buck DS","year":"1994","journal-title":"J Fam Pract"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1996.tb15654.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.15181","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T18:52:40Z","timestamp":1694717560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.15181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,28]]},"references-count":78,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/jdv.15181"],"URL":"https:\/\/doi.org\/10.1111\/jdv.15181","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,28]]},"assertion":[{"value":"2017-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}