{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:52:51Z","timestamp":1773978771720,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Shire GmbH, Zug, Switzerland"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Icatibant Outcome Survey (<jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content>;<jats:styled-content style=\"fixed-case\"> NCT<\/jats:styled-content>01034969) is a Shire\u2010sponsored, international, observational study monitoring the safety and effectiveness of icatibant, a bradykinin B2 receptor antagonist approved for the acute treatment of adults with hereditary angioedema with C1 inhibitor deficiency (<jats:styled-content style=\"fixed-case\">HAE<\/jats:styled-content>\u2010C1\u2010<jats:styled-content style=\"fixed-case\">INH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report <jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content> data comparing demographic and icatibant treatment outcomes in patients with <jats:styled-content style=\"fixed-case\">HAE<\/jats:styled-content>\u2010C1\u2010<jats:styled-content style=\"fixed-case\">INH<\/jats:styled-content> from Germany to <jats:styled-content style=\"fixed-case\">HAE<\/jats:styled-content>\u2010C1\u2010<jats:styled-content style=\"fixed-case\">INH<\/jats:styled-content> patients from 11 other <jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content> countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A descriptive, retrospective, comparative analysis of data from 685 <jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">HAE<\/jats:styled-content>\u2010C1\u2010<jats:styled-content style=\"fixed-case\">INH<\/jats:styled-content> from seven centres in Germany (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>93) vs. centres from Austria, Brazil, Czech Republic, Denmark, France, Greece, Israel, Italy, Spain, Sweden and the United Kingdom (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>592, July 2009\u2013January 2017). Icatibant treatment outcomes were retrieved from patients with complete attack outcome data for time to treatment, time to resolution and attack duration (160 attacks in 42 German patients and 1442 attacks in 251 patients from other <jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content> countries).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>German patients reported significantly fewer severe\/very severe attacks (38.7% vs. 57.5%, respectively; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). The proportion of attacks treated with a single icatibant injection was significantly higher in German patients (97.1% vs. 91.6%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0003). The median time to treatment (0.0\u00a0h vs. 1.5\u00a0h), time to resolution (3.0\u00a0h vs. 7.0\u00a0h) and attack duration (4.3\u00a0h vs. 10.5\u00a0h) in German patients vs. other <jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content> countries were all significantly shorter (all <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). No meaningful differences were identified between patients from Germany and other countries with regard to sex, median age at enrolment, median age at symptom onset and median age at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>German <jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content> patients share similar demographic characteristics to patients from other <jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content> countries yet treat their attacks with icatibant significantly earlier and have markedly fewer severe or very severe attacks. Factors including regional access to and availability of icatibant may drive these outcomes and warrant further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15232","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T16:05:47Z","timestamp":1535990747000},"page":"163-169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Management of patients with hereditary angioedema in Germany: comparison with other countries in the Icatibant Outcome Survey"],"prefix":"10.1111","volume":"33","author":[{"given":"M.","family":"Maurer","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Allergy Center Charit\u00e9 Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Bork","sequence":"additional","affiliation":[{"name":"Department of Dermatology Johannes Gutenberg University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Martinez\u2010Saguer","sequence":"additional","affiliation":[{"name":"HZRM Hemophilia Center Rhine Main M\u00f6rfelden\u2010Walldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Ayg\u00f6ren\u2010P\u00fcrs\u00fcn","sequence":"additional","affiliation":[{"name":"Department for Children and Adolescents Angioedema Centre University Hospital Frankfurt Goethe University Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Botha","sequence":"additional","affiliation":[{"name":"Shire Zug Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Andresen","sequence":"additional","affiliation":[{"name":"Shire Zug Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Magerl","sequence":"additional","affiliation":[{"name":"Department of 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12380"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.09.064"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.055"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13384"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-016-8546-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906393"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12303"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053773"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2014.35.3780"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000430864"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.08.014"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13103"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0102"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14251"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-017-0203-z"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-6-21"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-9-29"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.06.029"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2165\/11539190-000000000-00000"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2017.03.004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.09.023"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12244"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12209"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12007"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12900"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00212"}],"container-title":["Journal 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