{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:51:45Z","timestamp":1782741105499,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autologous non\u2010cultured epidermal cell suspension (NCES) is a successful surgical method for repigmentation of stable, refractory vitiligo. The need for laboratory equipment and expertise restricts its use to only a few research centres; hence, there is a requisite to simplify the technique of NCES preparation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy of NCES prepared by four compartment (4C) method compared to the laboratory\u2010based method (lab\u2010NCES).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Anatomically based matched lesions (41 pairs) in 30 stable vitiligo patients were randomized to receive NCES prepared by 4C method or lab\u2010NCES. Each patient was evaluated at 4, 8, 16 weeks after surgery by a blinded observer with regard to extent of repigmentation, colour match, patient global assessment (PGA) and pattern of repigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Repigmentation outcome in 4C method as compared to lab\u2010NCES was as follows: excellent (\u226590%) repigmentation: 34% vs. 37%, <jats:italic>P<\/jats:italic> = 1.000, good (\u226575%) repigmentation: 68% vs. 71%, <jats:italic>P<\/jats:italic> = 1.000; colour match: 59% vs. 54%, <jats:italic>P<\/jats:italic> = 0.794, patient satisfaction based on PGA score \u2013 23.02 vs. 23.39 (<jats:italic>P<\/jats:italic> = 0.210) and major pattern of repigmentation (diffuse) \u2013 76% vs. 71% (<jats:italic>P<\/jats:italic> = 0.618).<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>Short follow\u2010up period of 16 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Four compartment method is a simple and effective technique for vitiligo surgery in routine clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15234","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T14:03:54Z","timestamp":1535983434000},"page":"185-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Four compartment method as an efficacious and simplified technique for autologous non\u2010cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active\u2010controlled study"],"prefix":"10.1111","volume":"33","author":[{"given":"S.","family":"Mrigpuri","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology, and Leprology Postgraduate Institute of Medical Education and Research Chandigarh India"},{"name":"Neelkanth Multispeciality Hospital Mandi Himachal Pradesh 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