{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:46:46Z","timestamp":1774583206516,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The lip and surrounding perioral region are susceptible to non\u2010melanoma skin cancer, but the distribution of basal cell and squamous cell carcinoma on the cutaneous and vermilion lips has not been fully elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the distribution of cutaneous and vermilion lip non\u2010melanoma skin cancer and to better describe risk factors, anatomic location, treatment characteristics and oncologic outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective comparative case series of patients undergoing Mohs micrographic surgery (MMS) at a single academic centre for lip and perioral basal cell and squamous cell carcinoma was performed over a 5\u2010year period. Demographics, medical comorbidities, surgical characteristics and recurrence status were extracted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010five vermilion and 116 cutaneous lip cancers were identified. Basal cell carcinoma (<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>) was more common in the cutaneous perioral region, while squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) was more common on the vermilion lip (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>s were more common on the upper vermilion lip and <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>s were more common on the lower vermilion lip (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Within the cutaneous perioral region, both <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>s were more common on the upper perioral surface (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). Male gender was associated with lower lip <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.015). Smoking, immunosuppression, anticoagulant use and hydrochlorothiazide use were not associated with cancer type or location. Recurrences were rare, but more common in vermilion lip cancers (6.6%) compared to perioral cutaneous cancers (0.8%). Outcomes for all groups were similar; <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>s of the vermilion lip had significantly greater mean <jats:styled-content style=\"fixed-case\">MMS<\/jats:styled-content> stages (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) as did <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>s (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Basal cell carcinoma is more commonly encountered on the cutaneous lip, whereas <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> is more common on the vermilion lip. Within the vermilion lip, <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> favours the upper lip, while <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> favours the lower lip. Within the cutaneous perioral region, both <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> favour the upper cutaneous tissue. Early stage lip cancers are curable by Mohs micrographic surgery with rare recurrences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15263","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T21:17:42Z","timestamp":1538774262000},"page":"305-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characteristics of non\u2010melanoma skin cancers of the cutaneous perioral and vermilion lip treated by Mohs micrographic surgery"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5665-102X","authenticated-orcid":false,"given":"D.","family":"Queen","sequence":"first","affiliation":[{"name":"Columbia University Vagelos College of Physicians and Surgeons New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Knackstedt","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cleveland Clinic Foundation Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Polacco","sequence":"additional","affiliation":[{"name":"Section\u00a0of Otolaryngology Department of Surgery Dartmouth\u2010Hitchcock Medical Center Lebanon NH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.K.","family":"Collins","sequence":"additional","affiliation":[{"name":"Section\u00a0of Dermatology Department of Surgery Dartmouth Hitchcock Medical Center Lebanon NH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Warren Alpert Medical School at Brown University Providence RI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.H.","family":"Samie","sequence":"additional","affiliation":[{"name":"Columbia University Vagelos College of Physicians and Surgeons New York NY USA"},{"name":"Section\u00a0of Dermatology 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