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Following an epidemic of sensitization to methylchloroisothiazolinone\/methylisothiazolinone (<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>) in the 1980s, and more recently to<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, the Scientific Committee on Consumer Safety of the European Commission banned their use in leave\u2010on products, while restricting that in rinse\u2010off cosmetics. Despite a decreasing prevalence of<jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>from<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, cases caused by occupational exposure and non\u2010cosmetic isothiazolinone sources are on the rise. Moreover, sensitization to newer and lesser known isothiazolinones has been reported. This paper reviews the epidemiology of contact allergy to different isothiazolinones, clinical presentation of isothiazolinone\u2010induced<jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>, most relevant sensitization sources and potential cross\u2010reactions between isothiazolinone derivatives. 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