{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:14:32Z","timestamp":1791220472495,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T00:00:00Z","timestamp":1541721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The 8th edition of TNM has introduced new rules for staging cutaneous melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare TNM 7th and 8th editions in defining pathological stages of melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based series of 1847 skin melanoma from Romagna cancer registry (Italy) incident during 2003\u20132012 has been used to measure the agreement (with Cohen's kappa) between TNM 8th and 7th editions in defining melanoma stage. Disease\u2010specific survival has been computed for each stage according to TNM 7th and 8th.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The agreement between the two TNM editions was quite good when considered on average (kappa = 70.7%), moderate for stage I (61.5%), nearly perfect for stage II (95.0%), but extremely poor for stage III (8.1%). The overall melanoma\u2010specific observed survival was 90.8% at 5 year and 88.9% at 10 year with a strong prognostic effect of stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TNM 8th edition introduces several changes which do not seem really helpful in addressing the care of stage I melanoma and may complicate the definition and comparability of stage III.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15285","type":"journal-article","created":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T01:49:37Z","timestamp":1539481777000},"page":"521-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of the agreement between TNM 7th and 8th in a population\u2010based series of cutaneous melanoma"],"prefix":"10.1111","volume":"33","author":[{"given":"E.","family":"Crocetti","sequence":"first","affiliation":[{"name":"Romagna Cancer Registry IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) Meldola Italy"},{"name":"Dermatology Unit Department of Surgery and Translational Medicine University of Florence Medical School Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Stanganelli","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) Meldola Italy"},{"name":"University of Parma Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mancini","sequence":"additional","affiliation":[{"name":"Romagna Cancer Registry IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Vattiato","sequence":"additional","affiliation":[{"name":"Romagna Cancer Registry IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Giuliani","sequence":"additional","affiliation":[{"name":"Romagna Cancer Registry IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ravaioli","sequence":"additional","affiliation":[{"name":"Romagna Cancer Registry IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Balducci","sequence":"additional","affiliation":[{"name":"Romagna Cancer Registry IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Falcini","sequence":"additional","affiliation":[{"name":"Romagna Cancer Registry IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori 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