{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:39:52Z","timestamp":1790372392872,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,25]],"date-time":"2018-11-25T00:00:00Z","timestamp":1543104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Maternal prenatal psychiatric disease has been identified as a possible risk factor for atopic dermatitis development in her children. We quantified the associations between maternal and paternal psychiatric disease and the development of atopic dermatitis in their offspring using nationwide registries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All children in Denmark born between 1 January 1996 and 31 December 2011 who developed atopic dermatitis prior to their fifth birthday were identified and individually matched 1:10 with controls from the general population and with children receiving care in a similar ambulatory\/hospital setting. Conditional logistic regression was used to calculate odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) with 95% confidence intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 8602 children with atopic dermatitis were matched with controls. Rates of parental psychiatric care were similar in the atopic dermatitis and control groups. When compared to the general population, weak associations were found between childhood atopic dermatitis and maternal history of depression [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.18 (95% confidence interval: 1.12\u20131.26)], alcohol abuse [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.37 (1.17\u20131.60)] and illicit drug use [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.34 (1.14\u20131.60)]. However, associations became insignificant when the paediatric ambulatory\/hospital control group was used [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.05 (0.99\u20131.13)], [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.14 (0.98\u20131.34)] and [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.03 (0.88\u20131.22)], respectively. No paternal psychiatric disease or prenatal maternal psychiatric disease associated with the <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> development in the offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While we found no consistent associations between maternal or paternal psychiatric disease and the subsequent development of atopic dermatitis in their offspring, children of parents with substance abuse issues may be more likely to receive an atopic dermatitis diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15321","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T16:26:54Z","timestamp":1541089614000},"page":"725-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Exploring the association between parental psychiatric disease and childhood atopic dermatitis: a matched case\u2013control study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2011-7380","authenticated-orcid":false,"given":"C.R.","family":"Hamann","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"},{"name":"Copenhagen Research Group for Inflammatory Skin (CORGIS) Hellerup Denmark"},{"name":"School of Health and Medical Science Graduate Programme in Public Health and Epidemiology University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8257-1816","authenticated-orcid":false,"given":"A.","family":"Egeberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"},{"name":"Copenhagen Research Group for Inflammatory Skin (CORGIS) Hellerup 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