{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:09:13Z","timestamp":1787015353820,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Bullous pemphigoid (\n BP<\/jats:styled-content>\n ) is the most common autoimmune blistering disease.\n BP<\/jats:styled-content>\n 180 is the primary autoantigen of\n BP<\/jats:styled-content>\n , and in a portion of\n BP<\/jats:styled-content>\n cases,\n BP<\/jats:styled-content>\n 230 is the only target of autoantibodies. Such\n BP<\/jats:styled-content>\n is called\n BP<\/jats:styled-content>\n 230\u2010type\n BP<\/jats:styled-content>\n .\n BP<\/jats:styled-content>\n 230\u2010type\n BP<\/jats:styled-content>\n tends to show milder clinical phenotypes than conventional\n BP<\/jats:styled-content>\n , but the reason is unclear. The pathogenic roles of autoantibodies and complement activation have been shown in conventional\n BP<\/jats:styled-content>\n , but the distribution of IgG subclasses and the degree of complement deposition in\n BP<\/jats:styled-content>\n 230\u2010type\n BP<\/jats:styled-content>\n remain unclear.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To compare the distribution of IgG subclasses and the degree of complement deposition in\n BP<\/jats:styled-content>\n 230\u2010type\n BP<\/jats:styled-content>\n with those in conventional\n BP<\/jats:styled-content>\n with autoantibodies to\n BP<\/jats:styled-content>\n 180 and\n BP<\/jats:styled-content>\n 230 (\n BP<\/jats:styled-content>\n 180\u2010\n BP<\/jats:styled-content>\n 230\u2010type\n BP<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The diagnosis of\n BP<\/jats:styled-content>\n was confirmed by the histopathology of the lesions, the deposition of IgG and complement in the perilesional skin and the presence of circulating autoantibodies to\n BP<\/jats:styled-content>\n 180 and\n BP<\/jats:styled-content>\n 230. The disease severity was determined by bullous pemphigoid disease area index. The deposition of IgG subclasses and complement deposition were examined by direct immunofluorescence of the perilesional skin in 6\n BP<\/jats:styled-content>\n 230\u2010type\n BP<\/jats:styled-content>\n cases and 11\n BP<\/jats:styled-content>\n 180\u2010\n BP<\/jats:styled-content>\n 230\u2010type\n BP<\/jats:styled-content>\n cases.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Sixty seven percent of\n BP<\/jats:styled-content>\n 230\u2010type\n BP<\/jats:styled-content>\n cases show a mild clinical phenotype. All\n BP<\/jats:styled-content>\n 230\u2010type\n BP<\/jats:styled-content>\n cases and 82% of\n BP<\/jats:styled-content>\n 180\u2010\n BP<\/jats:styled-content>\n 230\u2010type\n BP<\/jats:styled-content>\n cases were found to demonstrate the clear deposition of IgG4 at the basement membrane zone of skin specimens. Notably, the deposition of IgG1 and IgG3 was faint or negative in all of the\n BP<\/jats:styled-content>\n 230\u2010type\n BP<\/jats:styled-content>\n cases, whereas they were clearly detected in 91% and 64% of the\n BP<\/jats:styled-content>\n 180\u2010\n BP<\/jats:styled-content>\n 230\u2010type\n BP<\/jats:styled-content>\n cases, respectively. The deposition of complement C3 tended to be weaker in\n BP<\/jats:styled-content>\n 230\u2010type\n BP<\/jats:styled-content>\n than in\n BP<\/jats:styled-content>\n 180\u2010\n BP<\/jats:styled-content>\n 230\u2010type\n BP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The mild clinical phenotype of\n BP<\/jats:styled-content>\n 230\u2010type\n BP<\/jats:styled-content>\n may correlate with the weaker deposition of IgG1, IgG3 and complement in the skin lesions.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.15325","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T06:42:59Z","timestamp":1541400179000},"page":"595-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Characteristics of IgG subclasses and complement deposition in\n BP<\/scp>\n 230\u2010type bullous pemphigoid"],"prefix":"10.1111","volume":"33","author":[{"given":"M.","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ujiie","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ujiie","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sapporo City General Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.C.","family":"Sato\u2010Matsumura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sapporo Hokushin Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo 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