{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:54:44Z","timestamp":1790589284354,"version":"4.1.0"},"reference-count":446,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pierre Fabre Dermo-Cosm\u00e9tique"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>For many decades and until recently, medical approach to dermatologic diseases has been based on the physician's ability to recognize and treat symptoms. Nowadays, advances in the understanding of the biology of diseases and in technologies for intervening against them have allowed physicians to diagnose and treat underlying disease processes rather than simply addressing the symptoms. This means that rather than addressing \u2018the disease in humans\u2019, physicians can now address the particular pathologic (biologic, molecular) disturbance as it presents in the individual patient, i.e., physicians now can practice something much closer to \u2018personalized medicine\u2019, leading to greater benefits for the patients and the health of society in general. The deeper understanding of ultraviolet radiation, the importance of photoprotection and increased knowledge about signalling pathways of melanoma and carcinoma have led to more complete care for the dermatologic patient. The current popularity for excessive exposure to the sun, without adequate application of the appropriate photoprotection remedies, is the origin of melanoma, but also for the weakening of the structure and functions of the skin. Indeed, fragility of the skin can affect humans around the world. In the senior population, this skin fragility is accompanied by pruritus, whereas atopic dermatitis is an inflammatory disease with highest prevalence in children and adolescents. Acne, the number one reason for dermatologic consultations worldwide, increases its prevalence in adolescents and in females. Senescent alopecia affects humans after menopause and andropause. The articles in this publication present an overview of the current advanced understanding of the diagnosis and therapeutic approaches in 6 fields of dermatology \u2013 dermatopaediatry and gerontodermatology, oncodermatology, hair loss, atopic dermatitis, photoprotection and acne \u2013 and thereby serve as a useful compendium of updated information and references for all healthcare professionals who see patients with presentations of the symptoms of these diseases.<\/jats:p>","DOI":"10.1111\/jdv.15335","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T08:46:47Z","timestamp":1545122807000},"page":"3-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Dermatology today and tomorrow: from symptom control to targeted therapy"],"prefix":"10.1111","volume":"33","author":[{"given":"U.","family":"Blume\u2010Peytavi","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bagot","sequence":"additional","affiliation":[{"name":"Dermatology Department Saint\u2010Louis Hospital, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Tennstedt","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saint\u2010Luc University Clinics Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Saint Aroman","sequence":"additional","affiliation":[{"name":"A\u2010Derma Dermatological Laboratoires Pierre Fabre Dermo\u2010Cosm\u00e9tique Lavaur France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Stockfleth","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie Venerologie und Allergologie St. Josef\u2010Hospital Ruhr\u2010Universit\u00e4t Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Zlotogorski","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hadassah Medical Center The Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Mengeaud","sequence":"additional","affiliation":[{"name":"Ducray Dermatological Laboratories Pierre Fabre Dermo\u2010Cosm\u00e9tique Lavaur France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Dermatology Innovation Unit Pierre Fabre Research and Development Institute Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Paul","sequence":"additional","affiliation":[{"name":"Dermatology Department Larrey Hospital UMR INSERM 1065 Paul Sabatier University Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.W.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Georgescu","sequence":"additional","affiliation":[{"name":"Av\u00e8ne Dermatological Laboratories Pierre Fabre Dermo\u2010Cosm\u00e9tique Lavaur France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Dr\u00e9no","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Oncology University Hospital Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nocera","sequence":"additional","affiliation":[{"name":"Department of Dermatology Clinical Research and Development Center Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12509"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13636"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.12658.1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14410"},{"key":"e_1_2_9_6_1","first-page":"289","article-title":"Epidemiology of \u201cfragile skin\u201d: results from a survey of different skin types","volume":"6","author":"Haftek M","year":"2013","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_9_7_1","unstructured":"Saint AromanM Blume\u2010PeytaviU ChalemYet\u00a0al.Fragility of epidermis: Epidemiology study in Germany. Poster 1027. Presented at the 26th EADV (European Academy of Dermatology and Venereology) Congress September 13\u201317 2017 Geneva Switzerland."},{"key":"e_1_2_9_8_1","unstructured":"Saint AromanM Al HammadiA NiarraR Le MauffA.Fragility of epidermis: Epidemiology study in Middle East population focus on United Arab Emirates. Poster 1030. Presented at the 26th EADV (European Academy of Dermatology and Venereology) Congress September 13\u201317 2017 Geneva Switzerland."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S128722"},{"key":"e_1_2_9_10_1","unstructured":"Saint AromanM ChiuP NiarraR Le MauffA.Fragility of epidermis: Epidemiology study in Asian population focus on Ta\u00efwan. Poster 1036. Presented at the 26th EADV (European Academy of Dermatology and Venereology) Congress September 13\u201317 2017 Geneva Switzerland."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000242513"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701239"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2015.0642"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13495"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14080"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.11138\/cderm\/2017.5.3.99"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/ddg.13594","article-title":"Basic skin care in atopic dermatitis \u2013 new and established treatment options","volume":"16","author":"Chylla R","year":"2018","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.11.011"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.005"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.060"},{"key":"e_1_2_9_21_1","unstructured":"WollenbergA Folster\u2010holstR BoraleviFet\u00a0al.Effects of a protein\u2010free oat plantlet extract on microinflammation and skin barrier function in newborns at risk to develop atopic dermatitis. Poster 160. 18th ESPD Annual Meeting 7\u20139 June 2018 Queen Elizabeth II Centre London UK.Pediatr Dermatol2018; 35(Suppl 2): S36."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1250649"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-2031-3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12469"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107621"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334631"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.07.005"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2016.04.001"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0b013e31823fe246"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475416653722"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-017-0507-1"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2014.02.012"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-015-0246-0"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2017.10.005"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12028"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1318"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319862"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1159"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.446"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1968"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00656.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.05.035"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2005.22201.x"},{"key":"e_1_2_9_44_1","unstructured":"NastA Guideline Subcommittee \u201cChronic Pruritus\u201d European Dermatology Forum (EDF).Update of the Guideline on Chronic Pruritus.EDF Zurich Switzerland 2014."},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13304_g"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13157"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1208814"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0746-9"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14077"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355671"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2893"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16014"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.223784"},{"key":"e_1_2_9_54_1","first-page":"137","article-title":"Topical capsaicin therapy for uremic pruritus in patients on hemodialysis","volume":"4","author":"Makhlough A","year":"2010","journal-title":"Iran J Kidney Dis"},{"key":"e_1_2_9_55_1","first-page":"437","article-title":"Safety and anti\u2010pruritic efficacy of a menthol\u2010containing moisturizing cream","volume":"15","author":"Tey H","year":"2017","journal-title":"SKINmed"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14041"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph9040077"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2047"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1444752"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.025"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.06.004"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.02.030"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2007.06.004"},{"key":"e_1_2_9_64_1","first-page":"193","article-title":"Prognostic factors in 1521 melanoma patients with distant metastases","volume":"181","author":"Barth A","year":"1995","journal-title":"J Am Coll Surg"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.3.1103"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)70937-5"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31559-9"},{"key":"e_1_2_9_68_1","first-page":"CD011123","article-title":"Systemic treatments for metastatic cutaneous melanoma","volume":"2","author":"Pasquali S","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12477"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.044"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22071"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2011.03.002"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00837.x"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00778.x"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.2984"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31345"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.04.001"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502583"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2122"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx339"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60868-X"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2014-0429"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408868"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60898-4"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412690"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30142-6"},{"issue":"5","key":"e_1_2_9_88_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/annonc\/mdx377.002","article-title":"Results of COLUMBUS Part 2: a phase 3 trial of encorafenib (ENCO) plus binimetinib (BINI) versus ENCO in BRAF\u2010mutant melanoma","volume":"28","author":"Dummer R","year":"2017","journal-title":"Ann Oncol"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.2668"},{"key":"e_1_2_9_90_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/CMR.0000000000000461","article-title":"High baseline neutrophil\u2010to\u2010lymphocyte ratio predicts worse outcome in patients with metastatic BRAF\u2010positive melanoma treated with BRAF and MEK inhibitors","volume":"28","author":"Teterycz P","year":"2018","journal-title":"Melanoma Res"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S120877"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.6270"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504030"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709684"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0336-3"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414428"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503093"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003466"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.2226"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491572"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14011"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.2707"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13520"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344413"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00310"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12519"},{"issue":"5","key":"e_1_2_9_107_1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/annonc\/mdx440.011","article-title":"Efficacy of BMS\u2010986016, a monoclonal antibody that targets lymphocyte activation gene\u20103 (LAG\u20103), in combination with nivolumab in pts with melanoma who progressed during prior anti\u2013PD\u20101\/PD\u2010L1 therapy (mel prior IO) in all\u2010comer and biomarker\u2010enriched populations. LBA18","volume":"28","author":"Ascierto PA","year":"2017","journal-title":"Ann Oncol"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0118"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-2837"},{"issue":"5","key":"e_1_2_9_110_1","first-page":"v428","article-title":"KEYNOTE\u2010022 update: phase 1 study of first\u2010line pembrolizumab (pembro) plus dabrafenib (D) and trametinib (T) for BRAF\u2010mutant advanced melanoma","volume":"28","author":"Ribas A","year":"2017","journal-title":"Ann Oncol"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.15_suppl.3063"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.9560"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.5_suppl.189"},{"key":"e_1_2_9_114_1","unstructured":"RocheH\u2010L.Study of atezolizumab plus cobimetinib and vemurafenib versus placebo plus cobimetinib and vemurafenib in previously untreated BRAFv600 mutation\u2010positive patients with metastatic or unresectable locally advanced melanoma. [WWW document] ClinicalTrials.gov Identifier: NCT02908672. URLhttps:\/\/clinicaltrials.gov\/ct2\/show\/NCT02908672(last accessed: 10 August 2018)."},{"key":"e_1_2_9_115_1","unstructured":"Idera Pharmaceuticals.Idera Pharmaceuticals Announces launch of global phase 3 Trial evaluating IMO\u20102125 in combination with ipilimumab for the treatment of anti\u2010PD\u20101 refractory melanoma (ILLUMINATE 301). [WWW docuemnt] Press release. 1 March2018. URLhttp:\/\/ir.iderapharma.com\/news-releases\/news-release-details\/idera-pharmaceuticals-announces-launch-global-phase-3-trial(last accessed: 10 September 2018)."},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.9515"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.01.001"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.75"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000246"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.3377"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.34.15_suppl.9568"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2017.12.009"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1708701"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0948-9"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S108171"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113713"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)70100-2"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14542"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.10.028"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.12.001"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.12.004"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30364-3"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-017-0310-x"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.7899"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13717"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30507-1"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.103342"},{"key":"e_1_2_9_138_1","first-page":"45","article-title":"Epidemiology of solar keratoses","volume":"131","author":"Frost CA","year":"1994","journal-title":"Br J Dermatol"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022137"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07378.x"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.182100"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02392.x"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.378"},{"key":"e_1_2_9_144_1","first-page":"201","article-title":"Progression of actinic keratosis to squamous cell carcinoma revisited: clinical and treatment implications","volume":"87","author":"Feldman SR","year":"2011","journal-title":"Cutis"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24284"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12848"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13626"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16048"},{"key":"e_1_2_9_149_1","first-page":"CD004415","article-title":"Brintnell W. Interventions for actinic keratoses","volume":"12","author":"Gupta AK","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12343"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14624"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2014.10.008"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12284"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.07.007"},{"key":"e_1_2_9_155_1","first-page":"434","article-title":"Histology and hormonal activity in senescent thinning in males","volume":"117","author":"Price V","year":"2001","journal-title":"J Invest Dermatol"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.06.017"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10856.x"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-018-1826-8"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.10.018"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.04.038"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12422"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.05.007"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12225"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2455-3"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2224-8"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05785.x"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2843"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.05.026"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003122"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jisp.2017.01.003"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2018.06.022"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.02157.x"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02255.x"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.12m07887"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2017.04.003"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13310"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2016.28.4.444"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13710"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567201815666180124112905"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.5414\/CP202119"},{"key":"e_1_2_9_181_1","article-title":"A randomized, double\u2010blind controlled study of the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil vs. 3% minoxidil solution in the treatment of male androgenetic alopecia","author":"Suchonwanit P","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_9_182_1","first-page":"457","article-title":"A systematic review of topical finasteride in the treatment of androgenetic alopecia in men and women","volume":"17","author":"Lee SW","year":"2018","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10010019"},{"key":"e_1_2_9_184_1","first-page":"1153","article-title":"Minoxidil dose response study in female pattern hair loss patients determined to be non\u2010responders to 5% topical minoxidil","volume":"30","author":"McCoy J","year":"2016","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12369"},{"key":"e_1_2_9_186_1","first-page":"874","article-title":"A phase III, multicenter, parallel\u2010design clinical trial to compare the efficacy and safety of 5% minoxidil foam versus vehicle in women with female pattern hair loss","volume":"15","author":"Bergfeld W","year":"2016","journal-title":"J\u00a0Drugs Dermatol"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2385-5"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2017.1400170"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.02.054"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0060-6"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12200"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2017.1400174"},{"key":"e_1_2_9_193_1","first-page":"221","article-title":"New treatments for hair loss","volume":"108","author":"Va\u00f1\u00f3\u2010Galv\u00e1n S","year":"2017","journal-title":"Actas Dermosifiliogr"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_74_16"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_27_17"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000665"},{"key":"e_1_2_9_197_1","article-title":"Platelet rich plasma for the management of hair loss: better alone or in combination?","author":"Anitua E","journal-title":"J Cosmet Dermatol"},{"key":"e_1_2_9_198_1","article-title":"Trichologic response of platelet\u2010rich plasma in androgenetic alopecia is maintained during combination therapy","author":"Ho A","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000883"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477671"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12650"},{"key":"e_1_2_9_202_1","first-page":"e10","article-title":"Hair regeneration treatment using adipose\u2010derived stem cell conditioned medium: follow\u2010up with trichograms","volume":"15","author":"Fukuoka H","year":"2015","journal-title":"Eplasty"},{"key":"e_1_2_9_203_1","doi-asserted-by":"publisher","DOI":"10.1177\/2041731414556850"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2016.1227419"},{"key":"e_1_2_9_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2017.09.008"},{"issue":"3","key":"e_1_2_9_206_1","doi-asserted-by":"crossref","DOI":"10.5070\/D3203021754","article-title":"Follicular unit extraction hair transplant harvest: a review of current recommendations and future considerations","volume":"20","author":"Bicknell LM","year":"2014","journal-title":"Dermatol Online J"},{"key":"e_1_2_9_207_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369416"},{"key":"e_1_2_9_208_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001316"},{"key":"e_1_2_9_209_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S172638"},{"key":"e_1_2_9_210_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.0001"},{"key":"e_1_2_9_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.09.007"},{"key":"e_1_2_9_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.02.015"},{"key":"e_1_2_9_213_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.89790"},{"key":"e_1_2_9_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.03.024"},{"key":"e_1_2_9_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.10.043"},{"key":"e_1_2_9_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jisp.2017.10.005"},{"key":"e_1_2_9_217_1","unstructured":"Incyte reports 2017 first\u2010quarter financial results and updates on key clinical programs. [WWW document] News release 4 May2017. URLhttps:\/\/investor.incyte.com\/news-releases\/news-release-details\/incyte-reports-2017-first-quarter-financial-results-and-updates(last accessed: 30 August 2018)."},{"key":"e_1_2_9_218_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0542-7"},{"key":"e_1_2_9_219_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3569"},{"key":"e_1_2_9_220_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0001-z"},{"key":"e_1_2_9_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2017.02.004"},{"key":"e_1_2_9_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.07.042"},{"key":"e_1_2_9_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2017.03.006"},{"key":"e_1_2_9_224_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.88"},{"key":"e_1_2_9_225_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1767"},{"key":"e_1_2_9_226_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011040"},{"key":"e_1_2_9_227_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14997"},{"key":"e_1_2_9_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.04.031"},{"key":"e_1_2_9_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.12.1566"},{"key":"e_1_2_9_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.01.048"},{"key":"e_1_2_9_231_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051745"},{"key":"e_1_2_9_232_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1852"},{"key":"e_1_2_9_233_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14891"},{"key":"e_1_2_9_234_1","first-page":"CD012119","article-title":"Emollients and moisturisers for eczema","volume":"2","author":"Zuuren EJ","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_235_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14846"},{"key":"e_1_2_9_236_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7350.1376"},{"key":"e_1_2_9_237_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-1990"},{"key":"e_1_2_9_238_1","doi-asserted-by":"publisher","DOI":"10.1159\/000484407"},{"key":"e_1_2_9_239_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.11.056"},{"key":"e_1_2_9_240_1","doi-asserted-by":"publisher","DOI":"10.4161\/jkst.24137"},{"key":"e_1_2_9_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.04.018"},{"key":"e_1_2_9_242_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.12.024"},{"key":"e_1_2_9_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2014.01.004"},{"key":"e_1_2_9_244_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-64804-0_12"},{"key":"e_1_2_9_245_1","volume-title":"Adherence to Treatment in Medical Conditions","author":"Horne R","year":"1998"},{"key":"e_1_2_9_246_1","volume-title":"Adherence to Long\u2010Term Therapies: Evidence for Action","author":"Sabat\u00e9 E","year":"2003"},{"key":"e_1_2_9_247_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0253-5"},{"key":"e_1_2_9_248_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.2437"},{"key":"e_1_2_9_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.02.031"},{"key":"e_1_2_9_250_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1306017"},{"key":"e_1_2_9_251_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12402"},{"key":"e_1_2_9_252_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1350256"},{"key":"e_1_2_9_253_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.148.s63.1.x"},{"key":"e_1_2_9_254_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.06.042"},{"key":"e_1_2_9_255_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14888"},{"key":"e_1_2_9_256_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14238"},{"key":"e_1_2_9_257_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13599"},{"key":"e_1_2_9_258_1","doi-asserted-by":"publisher","DOI":"10.1159\/000484406"},{"key":"e_1_2_9_259_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2018.1449642"},{"key":"e_1_2_9_260_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S123329"},{"key":"e_1_2_9_261_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610020"},{"key":"e_1_2_9_262_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31191-1"},{"key":"e_1_2_9_263_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314768"},{"key":"e_1_2_9_264_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00388-8"},{"key":"e_1_2_9_265_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.2690"},{"key":"e_1_2_9_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.01.034"},{"key":"e_1_2_9_267_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606490"},{"key":"e_1_2_9_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.03.018"},{"key":"e_1_2_9_269_1","article-title":"Treatment of atopic dermatitis with tralokinumab, an anti\u2010IL\u201013 mAb","author":"Wollenberg A","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_9_270_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.01.017"},{"issue":"105","key":"e_1_2_9_271_1","first-page":"77","article-title":"First\u2010in\u2010class phase 2a study of ANB020 (anti\u2010IL\u201033) in the treatment of moderate\u2010to\u2010severe atopic dermatitis","volume":"73","author":"Chen YL","year":"2018","journal-title":"Allergy"},{"key":"e_1_2_9_272_1","unstructured":"Tha\u00e7iD.MOR106 an anti\u2010IL\u201017C mAb a potential new approach for treatment of moderate\u2010to\u2010severe atopic dermatitis: Phase 1 study. Presented at the 2018 American Academy of Dermatology (AAD) Annual Meeting 16\u201320 February2018 San Diego CA."},{"issue":"3","key":"e_1_2_9_273_1","doi-asserted-by":"crossref","first-page":"AB245","DOI":"10.1016\/j.jaad.2018.05.976","article-title":"Results from a randomized, double\u2010blind, placebo\u2010controlled, exploratory, multicenter study of GBR 830 in adult patients with moderate\u2010to\u2010severe atopic dermatitis","volume":"79","author":"Guttman\u2010Yassky E","year":"2018","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"e_1_2_9_274_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.12.004"},{"key":"e_1_2_9_275_1","article-title":"Baricitinib in adult patients with moderate\u2010to\u2010severe atopic dermatitis: a phase 2 parallel, double\u2010blinded, randomized placebo\u2010controlled multiple\u2010dose study","author":"Guttman\u2010Yassky E","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"e_1_2_9_276_1","unstructured":"Guttman\u2010YaskyE.Primary results from a Phase 2b randomized placebo\u2010controlled trial of upadacitinib for patients with atopic dermatitis. Presented at the 2018 American Academy of Dermatology (AAD) Annual Meeting 16\u201320 February2018 San Diego CA."},{"key":"e_1_2_9_277_1","unstructured":"GooderhamM FormanS BissonnetteRet\u00a0al.PF\u201004965842 a selective JAK1 inhibitor for treatment of moderate\u2010severe atopic dermatitis: a 12\u00a0week randomized double blind placebo controlled Phase 2 clinical trial. Presented at the 26th European Academy of Dermatology and Venereology (EADV) Congress 13\u201317 September2017 Geneva Switzerland."},{"key":"e_1_2_9_278_1","unstructured":"BissonnetteR.Efficacy and safety of oral ASN002 a novel JAK\/SYK inhibitor in patients with moderate\u2010to\u2010severe atopic dermatitis: a randomized double\u2010blind placebo\u2010controlled clinical study. Presented at the 2018 American Academy of Dermatology (AAD) Annual Meeting. 16\u201320 February2018; San Diego CA."},{"issue":"3","key":"e_1_2_9_279_1","doi-asserted-by":"crossref","first-page":"AB300","DOI":"10.1016\/j.jaad.2018.05.1184","article-title":"Tradipitant improves worst itch and disease severity in patients with chronic pruritus related to atopic dermatitis","volume":"79","author":"Heitman A","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_9_280_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08149.x"},{"key":"e_1_2_9_281_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-010-0162-7"},{"issue":"102","key":"e_1_2_9_282_1","first-page":"95","article-title":"A phase 2a proof of concept clinical trial to evaluate ZPL\u20103893787 (ZPL\u2010389), a potent, oral histamine H4 receptor antagonist for the treatment of moderate to severe atopic dermatitis (AD) in adults","volume":"71","author":"Werfel T","year":"2016","journal-title":"Allergy"},{"key":"e_1_2_9_283_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.006"},{"key":"e_1_2_9_284_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31527"},{"key":"e_1_2_9_285_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1253735"},{"key":"e_1_2_9_286_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.10.015"},{"key":"e_1_2_9_287_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11090.x"},{"key":"e_1_2_9_288_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.762"},{"key":"e_1_2_9_289_1","first-page":"1","article-title":"Part D: radiation. A review of human carcinogens","volume":"100","author":"International Agency for Research on Cancer Monograph Working Group","year":"2012","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"e_1_2_9_290_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08658"},{"key":"e_1_2_9_291_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11081.x"},{"key":"e_1_2_9_292_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4757"},{"key":"e_1_2_9_293_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600849"},{"key":"e_1_2_9_294_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256022"},{"key":"e_1_2_9_295_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30459"},{"key":"e_1_2_9_296_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5039"},{"key":"e_1_2_9_297_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)12168-2"},{"key":"e_1_2_9_298_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.5934"},{"key":"e_1_2_9_299_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0352"},{"key":"e_1_2_9_300_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.7078"},{"key":"e_1_2_9_301_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.11.009"},{"key":"e_1_2_9_302_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.116"},{"key":"e_1_2_9_303_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.12.003"},{"key":"e_1_2_9_304_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2015.12.014"},{"key":"e_1_2_9_305_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2014.03.006"},{"key":"e_1_2_9_306_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2010.00838.x"},{"key":"e_1_2_9_307_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.12375"},{"key":"e_1_2_9_308_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12273"},{"key":"e_1_2_9_309_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.95"},{"key":"e_1_2_9_310_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15940"},{"key":"e_1_2_9_311_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.476"},{"key":"e_1_2_9_312_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.08.023"},{"key":"e_1_2_9_313_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2006.04.008"},{"key":"e_1_2_9_314_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18924-4"},{"key":"e_1_2_9_315_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000025"},{"key":"e_1_2_9_316_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.10.013"},{"key":"e_1_2_9_317_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2006.00212.x"},{"key":"e_1_2_9_318_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2012.01280.x"},{"key":"e_1_2_9_319_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2017.08.015"},{"key":"e_1_2_9_320_1","volume-title":"EWG's 12th Annual Sunscreen Guide","author":"Environmental Working Group (EWG)","year":"2018"},{"key":"e_1_2_9_321_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.11269"},{"key":"e_1_2_9_322_1","unstructured":"Scientific Committee on Consumer Safety European Commission.Commission Regulation (EU) 2017\/238 of 10 February 2017 amending Annex VI to Regulation (EC) No 1223\/2009 of the European Parliament and of the Council on cosmetic products. Official Journal of the European Union. 11 February2017; L36\/37."},{"key":"e_1_2_9_323_1","volume-title":"SCCP\/1201\/08. SCCP Opinion on Benzophenone\u20103. COLIPA n\u00b0 S38","author":"Scientific Committee on Consumer Products, Health & Consumer Protection Directorate\u2010General, European Commission","year":"2008"},{"key":"e_1_2_9_324_1","article-title":"Review of environmental effects of oxybenzone and other sunscreen active ingredients","author":"Schneider SL","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_9_325_1","unstructured":"Office of The Honorable David Y. Ige Governor State of Hawaii.David Ige signs bill making Hawaii first in the world to ban certain sunscreens. [WWW document] News release. 3 July2018. URLhttps:\/\/governor.hawaii.gov\/newsroom\/latest-news\/office-of-the-governor-news-release-governor-david-ige-signs-bill-making-hawaii-first-in-the-world-to-ban-certain-sunscreens\/(last accessed: 6 September 2018)."},{"key":"e_1_2_9_326_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000240"},{"key":"e_1_2_9_327_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12154"},{"key":"e_1_2_9_328_1","first-page":"389","volume-title":"Nanotechnology Environmental Health and Safety: Risks, Regulation and Management","author":"McCall MJ","year":"2019"},{"key":"e_1_2_9_329_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2011.07.006"},{"key":"e_1_2_9_330_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.08.022"},{"key":"e_1_2_9_331_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.5944"},{"key":"e_1_2_9_332_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2018.03.062"},{"key":"e_1_2_9_333_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.05.108"},{"key":"e_1_2_9_334_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03916.x"},{"key":"e_1_2_9_335_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.030528897"},{"key":"e_1_2_9_336_1","first-page":"570","article-title":"Reduced ultraviolet\u2010induced DNA damage and apoptosis in human skin with topical application of a photolyase\u2010containing DNA repair enzyme cream: clues to skin cancer prevention","volume":"5","author":"Berardesca E","year":"2012","journal-title":"Mol Med Rep"},{"key":"e_1_2_9_337_1","doi-asserted-by":"crossref","first-page":"AB156","DOI":"10.1016\/j.jaad.2011.11.656","article-title":"Photolyase sunscreen decreases expression of p53 and Ki67 in comparison to standard 50 SPF. Poster 5698","volume":"66","author":"Vidal\u2010Asensi S","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_9_338_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14721"},{"key":"e_1_2_9_339_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.04.040"},{"key":"e_1_2_9_340_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.322"},{"key":"e_1_2_9_341_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2017.3978"},{"key":"e_1_2_9_342_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2011.08.010"},{"key":"e_1_2_9_343_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd11.140191"},{"key":"e_1_2_9_344_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1005999"},{"key":"e_1_2_9_345_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1684\/ejd.2013.2214","article-title":"Melanoma attributable to sunbed use and tan seeking behaviours: an Italian survey","volume":"24","author":"Gandini S","year":"2014","journal-title":"Eur J Dermatol"},{"key":"e_1_2_9_346_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.6896"},{"key":"e_1_2_9_347_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.010"},{"key":"e_1_2_9_348_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.12.038"},{"key":"e_1_2_9_349_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.8.1047"},{"key":"e_1_2_9_350_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03882.x"},{"key":"e_1_2_9_351_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.032"},{"key":"e_1_2_9_352_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.02.018"},{"key":"e_1_2_9_353_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.06.007"},{"key":"e_1_2_9_354_1","unstructured":"FengJ KimY KomidesMet\u00a0al.Correlates of positive parental attitudes towards indoor tanning. Presented at the Annual Meeting of the American Academy of Dermatology 16\u201320 February2018.San Diego CA USA."},{"key":"e_1_2_9_355_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.6.1124"},{"key":"e_1_2_9_356_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.5898"},{"key":"e_1_2_9_357_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.1623"},{"key":"e_1_2_9_358_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-2404"},{"key":"e_1_2_9_359_1","unstructured":"Division of Cancer Prevention and Control Centers for Disease Control and Prevention (CDC).Indoor tanning is not safe. [WWW document] Atlanta GA: 2018. URLhttps:\/\/www.cdc.gov\/cancer\/skin\/basic_info\/indoor_tanning.htm(last accessed: 6 September 2018)."},{"key":"e_1_2_9_360_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61729-2"},{"key":"e_1_2_9_361_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.5538"},{"key":"e_1_2_9_362_1","first-page":"40","article-title":"A comprehensive critique and review of published measures of acne severity","volume":"9","author":"Agnew T","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_9_363_1","first-page":"79","article-title":"Evolution of acne assessments and impact on acne medications: an evolving, imperfect paradigm","volume":"15","author":"Stein Gold L","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_364_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.078"},{"key":"e_1_2_9_365_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13776"},{"key":"e_1_2_9_366_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.037"},{"key":"e_1_2_9_367_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2007.00037"},{"key":"e_1_2_9_368_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03685.x"},{"key":"e_1_2_9_369_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-017-0192-7"},{"key":"e_1_2_9_370_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-017-0185-2"},{"key":"e_1_2_9_371_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13190"},{"key":"e_1_2_9_372_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2016.1145338"},{"key":"e_1_2_9_373_1","first-page":"582","article-title":"Adapalene\/benzoyl peroxide gel 0.3%\/2.5%: effective acne therapy regardless of age or gender","volume":"16","author":"Stein Gold L","year":"2017","journal-title":"J\u00a0Drugs Dermatol"},{"key":"e_1_2_9_374_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14026"},{"key":"e_1_2_9_375_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0352-y"},{"key":"e_1_2_9_376_1","first-page":"1134","article-title":"Management of severe acne vulgaris with topical therapy","volume":"16","author":"Stein Gold L","year":"2017","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_377_1","first-page":"655","article-title":"The development of antimicrobial resistance due to the antibiotic treatment of acne vulgaris: a review","volume":"9","author":"Patel M","year":"2010","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_378_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00527-7"},{"key":"e_1_2_9_379_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1684\/ejd.2015.2685","article-title":"Bacteriological resistance in acne: a call to action","volume":"26","author":"Dr\u00e9no B","year":"2016","journal-title":"Eur J Dermatol"},{"key":"e_1_2_9_380_1","first-page":"1434","article-title":"In vivo antibacterial effects of tretinoin\u2010clindamycin and clindamycin alone on Propionibacterium acnes with varying clindamycin minimum inhibitory concentration levels","volume":"11","author":"Leyden JJ","year":"2012","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_381_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700289"},{"key":"e_1_2_9_382_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10392.x"},{"key":"e_1_2_9_383_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.111"},{"key":"e_1_2_9_384_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S137794"},{"key":"e_1_2_9_385_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090658"},{"key":"e_1_2_9_386_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2013.2033"},{"key":"e_1_2_9_387_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20143024"},{"key":"e_1_2_9_388_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.028"},{"key":"e_1_2_9_389_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2017.1344641"},{"key":"e_1_2_9_390_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15745"},{"key":"e_1_2_9_391_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.12.028"},{"key":"e_1_2_9_392_1","unstructured":"European Medicines Agency (EMA).Updated measures for pregnancy prevention during retinoid use. [WWW document]London UK:EMA: 21 June2018. URLhttp:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Referrals_document\/Retinoids_31\/European_Commission_final_decision\/WC500251247.pdf(last accessed: 1 September 2018)."},{"key":"e_1_2_9_393_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.1344"},{"key":"e_1_2_9_394_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.387"},{"key":"e_1_2_9_395_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12079"},{"key":"e_1_2_9_396_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10152.x"},{"key":"e_1_2_9_397_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2017.3062"},{"key":"e_1_2_9_398_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0349-6"},{"key":"e_1_2_9_399_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0245-x"},{"issue":"7","key":"e_1_2_9_400_1","first-page":"CD004425","article-title":"Combined oral contraceptive pills for treatment of acne","author":"Arowojolu AO","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_401_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2016.2773"},{"key":"e_1_2_9_402_1","first-page":"541","article-title":"Low doses of zinc gluconate for inflammatory acne","volume":"69","author":"Dr\u00e9no B","year":"1989","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_9_403_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2007.07.001"},{"key":"e_1_2_9_404_1","first-page":"542","article-title":"The clinical effects of zinc as a topical or oral agent on the clinical response and pathophysiologic mechanisms of acne: a systematic review of the literature","volume":"12","author":"Brandt S","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_405_1","first-page":"4","article-title":"The noncompliant patient with acne","volume":"16","author":"Tanghetti EA","year":"2011","journal-title":"Skin Therapy Lett"},{"key":"e_1_2_9_406_1","doi-asserted-by":"publisher","DOI":"10.1159\/000165628"},{"key":"e_1_2_9_407_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04416.x"},{"key":"e_1_2_9_408_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-014-0063-y"},{"key":"e_1_2_9_409_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2010.00490.x"},{"key":"e_1_2_9_410_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.10.011"},{"key":"e_1_2_9_411_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14881"},{"key":"e_1_2_9_412_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.10.012"},{"key":"e_1_2_9_413_1","first-page":"CD007917","article-title":"Posadzki P, light therapies for acne","volume":"9","author":"Barbaric J","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_414_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20276"},{"key":"e_1_2_9_415_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170600735912"},{"key":"e_1_2_9_416_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20412"},{"key":"e_1_2_9_417_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12186"},{"key":"e_1_2_9_418_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2294-7"},{"key":"e_1_2_9_419_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0255-3"},{"key":"e_1_2_9_420_1","first-page":"45","article-title":"Long\u2010pulsed dye laser\u2010mediated photodynamic therapy combined with topical therapy for mild to severe comedonal, inflammatory, or cystic acne","volume":"5","author":"Alexiades\u2010Armenakas M","year":"2006","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_421_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.04.030"},{"key":"e_1_2_9_422_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01200.x"},{"key":"e_1_2_9_423_1","first-page":"518","article-title":"Advancing the care of post\u2010acne scarring: expert insights into new treatment options","volume":"15","author":"Werschler WP","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_424_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.07.029"},{"key":"e_1_2_9_425_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/893080"},{"key":"e_1_2_9_426_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22410"},{"key":"e_1_2_9_427_1","first-page":"12","article-title":"Acne scarring\u2010pathogenesis, evaluation, and treatment options","volume":"10","author":"Connolly D","year":"2017","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_9_428_1","first-page":"CD011946","article-title":"Interventions for acne scars","volume":"4","author":"Abdel Hay R","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_429_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12095"},{"key":"e_1_2_9_430_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12207"},{"key":"e_1_2_9_431_1","first-page":"50","article-title":"Atrophic acne scarring: a review of treatment options","volume":"8","author":"Hession MT","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_9_432_1","first-page":"18","article-title":"Acne vulgaris and the epidermal barrier. Is acne vulgaris associated with inherent epidermal abnormalities that cause impairment of barrier functions? Do any topical acne therapies alter the structural and\/or functional integrity of the epidermal barrier?","volume":"6","author":"Thiboutot D","year":"2013","journal-title":"J\u00a0Clin Aesthet Dermatol"},{"key":"e_1_2_9_433_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13579"},{"key":"e_1_2_9_434_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(10)70053-3"},{"key":"e_1_2_9_435_1","doi-asserted-by":"publisher","DOI":"10.2165\/0128071-200910001-00001"},{"key":"e_1_2_9_436_1","first-page":"22","article-title":"Efficacy, safety, and subject satisfaction of a specified skin care regimen to cleanse, medicate, moisturize, and protect the skin of patients under treatment for acne vulgaris","volume":"8","author":"Rosso JQ","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"issue":"5","key":"e_1_2_9_437_1","first-page":"3","article-title":"The use of therapeutic moisturizers in various dermatologic disorders","volume":"68","author":"Bikowski J","year":"2001","journal-title":"Cutis"},{"key":"e_1_2_9_438_1","first-page":"1170","article-title":"Stratum corneum abnormalities and disease\u2010affected skin: strategies for successful outcomes in inflammatory acne","volume":"15","author":"Jordan L","year":"2016","journal-title":"J\u00a0Drugs Dermatol"},{"key":"e_1_2_9_439_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12720"},{"key":"e_1_2_9_440_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12520"},{"key":"e_1_2_9_441_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12791"},{"key":"e_1_2_9_442_1","first-page":"e909","article-title":"Fragility of the epidermis, a common pathophysiological mechanism of acne vulgaris, rosacea and reactive skin involving inflammasome activation","volume":"2","author":"Fabbrocini G","year":"2015","journal-title":"Inflamm Cell Signal"},{"key":"e_1_2_9_443_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055380"},{"key":"e_1_2_9_444_1","doi-asserted-by":"publisher","DOI":"10.1159\/000362491"},{"key":"e_1_2_9_445_1","first-page":"385","article-title":"Physiological effect of a probiotic on skin","volume":"63","author":"Muizzuddin N","year":"2012","journal-title":"J Cosmet Sci"},{"key":"e_1_2_9_446_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15043"},{"key":"e_1_2_9_447_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15042"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.15335","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T15:56:54Z","timestamp":1775318214000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.15335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,18]]},"references-count":446,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/jdv.15335"],"URL":"https:\/\/doi.org\/10.1111\/jdv.15335","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,18]]},"assertion":[{"value":"2018-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}