{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:40:06Z","timestamp":1789429206028,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Venous Leg Ulcers (<jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content>) occur in about 1% of the Western population. A <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content> takes 3\u201312\u00a0months to heal, it recurs often, and it has a negative impact on the quality of life. The risk factors for the development of a first <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content> are not well\u2010understood and prevention of a first <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content> therefore remains underappreciated. The aim of this study was to identify risk factors for developing a first <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content> in adults (aged\u00a0&gt;\u00a018\u00a0years) by searching the literature. We searched the Cochrane Library, Pubmed, Cinalh and Narcisto identify studies that investigated risk factors in developing a <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content>. The last search was performed in January 2018. Two reviewers independently reviewed the abstracts and full\u2010text articles, and assessed the methodological quality of the included studies. Results of studies using duplex scanning, and comparing participants with and without <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content>s were included in the qualitative analysis. Where possible a quantitative meta\u2010analysis was conducted. We found five studies that investigated the relation of several risk factors with <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content> development. The methodological differences of the studies made it impossible to perform a quantitative analysis. The risk factors higher age (four studies), higher body mass index (four studies), low physical activity (four studies), arterial hypertension (four studies), deep vein reflux (three studies), deep venous thrombosis (three studies) and family history of <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content> (three studies) were significantly associated with a <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content> in the majority of the studies. To what extent they influence the development of a <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content> remains unclear because of the limited number of studies that investigated the association of these risk factors with <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content> development, and the heterogeneity of these studies. Further studies are needed to confirm the association of these risk factors with the development of a <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content> and to explore overweight and low physical activity in more detail.<\/jats:p>","DOI":"10.1111\/jdv.15343","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T14:03:13Z","timestamp":1542117793000},"page":"1241-1248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["A systematic review on risk factors in developing a first\u2010time Venous Leg Ulcer"],"prefix":"10.1111","volume":"33","author":[{"given":"A.M.","family":"Meulendijks","sequence":"first","affiliation":[{"name":"Julius Center of Health Care Sciences Nursing Science University Medical Centre Utrecht Utrecht The Netherlands"},{"name":"Research Centre for Healthy and Sustainable Living University of Applied Sciences Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.M.C.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Research Centre for Healthy and Sustainable Living University of Applied Sciences Utrecht Utrecht The Netherlands"},{"name":"Raboud University Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"van Dooren","sequence":"additional","affiliation":[{"name":"Research Centre for Healthy and Sustainable Living University of Applied Sciences Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Schuurmans","sequence":"additional","affiliation":[{"name":"Julius Center of Health Care Sciences Nursing Science University Medical Centre Utrecht Utrecht The Netherlands"},{"name":"Research Centre for Healthy and Sustainable Living University of Applied Sciences Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.A.M.","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2004.05.015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331970105200102"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2014.09.008"},{"key":"e_1_2_7_5_1","unstructured":"RabeE KoA BerbothG PannierF.[Les facteurs environnementaux et la maladie veineuse chronique].Paper presented at 64es Journees Internationales Francophones D'Angeiologie. 27\u201028 Jan 2012 (Paris France. 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