{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T06:53:43Z","timestamp":1781506423455,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011110","name":"UCB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011110","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hidradenitis suppurativa (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) substantially affects health\u2010related quality\u2010of\u2010life outcomes. Most treatment options are supported by low quality of evidence without validated outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the efficacy of surgical and medical interventions using physician\u2010 and patient\u2010reported outcomes registered in <jats:styled-content style=\"fixed-case\">HISREG<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were extracted for all adult patients registered in <jats:styled-content style=\"fixed-case\">HISREG<\/jats:styled-content> between January 2013 and April 2016. Primary endpoints included Dermatology Life Quality Index (<jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>) scores, pain as measured using a numeric rating scale (<jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content>), Sartorius score and Hurley classification. Minimum clinically important differences (<jats:styled-content style=\"fixed-case\">MCID<\/jats:styled-content>s) for <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content> pain were analysed. Secondary endpoints included comparisons among different treatment groups, safety and complications of various treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and fifty\u2010five patients were included in the study: 31, 188, and 36 patients had Hurley stages I, <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> disease, respectively. Treatment with <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> lasers was the most common treatment modality. One hundred and forty\u2010nine patients (58.4%) were treated with surgical intervention, 87 (34.1%) received antibiotics and\/or anti\u2010inflammatory treatments, and 19 (7.5%) were treated with both surgery and medical intervention. No patients received biologic treatment. In patients with surgical treatments, Sartorius scores were significantly improved compared with baseline (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), 83 patients (55%) achieved a <jats:styled-content style=\"fixed-case\">DLQI MCID<\/jats:styled-content>, and 75 patients (49.7%) achieved an <jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content> pain <jats:styled-content style=\"fixed-case\">MCID<\/jats:styled-content>. In patients with medical treatments, Sartorius scores were not significantly improved compared with baseline (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.582); 25 patients (28%) achieved a <jats:styled-content style=\"fixed-case\">DLQI MCID<\/jats:styled-content> and 28 patients (31%) achieved an <jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content> pain <jats:styled-content style=\"fixed-case\">MCID<\/jats:styled-content>. In patients treated with surgical and medical combination, 9 (48%) achieved <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content> pain <jats:styled-content style=\"fixed-case\">MCID<\/jats:styled-content>s and Sartorius scores were significantly improved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> laser treatment is more effective than the non\u2010biologic medical treatments in this analysis based on physician\u2010 and patient\u2010derived outcomes. The study provides limited evidence for the combination of medical and surgical therapies in patients with <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15353","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T13:01:44Z","timestamp":1542632504000},"page":"1164-1171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Evaluation of medical and surgical treatments for hidradenitis suppurativa using real\u2010life data from the Scandinavian registry (<scp>HISREG<\/scp>)"],"prefix":"10.1111","volume":"33","author":[{"given":"\u00d8.","family":"Grimstad","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital of North Norway Troms\u00f8 Norway"},{"name":"Department of Clinical Medicine UiT The Arctic University of Norway Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Tzellos","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine UiT The Arctic University of Norway Troms\u00f8 Norway"},{"name":"Department of Dermatology University Hospital of North Norway Harstad Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.N.","family":"Dufour","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of North Norway Troms\u00f8 Norway"},{"name":"HISREG\u2010Registry for Hidradenitis Suppurativa University Hospital of North Norway Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8.","family":"Bremnes","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of North Norway Troms\u00f8 Norway"},{"name":"HISREG\u2010Registry for Hidradenitis Suppurativa University Hospital of North Norway Troms\u00f8 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