{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:14:27Z","timestamp":1759335267879,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T00:00:00Z","timestamp":1550448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"SURDNA Foundation fellowship through the Brown Center for Gerontology and Healthcare Research"},{"name":"Department of Dermatology, Warren Alpert Medical School of Brown University"},{"name":"Nurses\u2019 Health Study II grant","award":["UM1 CA176726"],"award-info":[{"award-number":["UM1 CA176726"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epidemiologic studies of atopic dermatitis (AD) are often limited by case definitions that have not been validated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>In this study, we assessed the accuracy of self\u2010report of AD in a large cohort of <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> female nurses, the Nurses\u2019 Health Study 2 (<jats:styled-content style=\"fixed-case\">NHS<\/jats:styled-content>2). We also provide clinical characteristics of AD in the cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We sent an electronic questionnaire to <jats:styled-content style=\"fixed-case\">NHS<\/jats:styled-content>2 participants who previously reported ever having a diagnosis of AD. This questionnaire was designed to confirm cases of AD using previously validated algorithms with &gt;85% specificity. We assessed the association of AD with asthma, comparing the results when different definitions of AD were applied. We also inquired about various aspects of participants\u2019 AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Responses were received from 2509 of 5126 (49%) nurses who were sent the questionnaire, with an average age of 62. Most participants (1996\/2509, 80%) reiterated their previously reported clinician diagnosis of AD. Application of the two diagnostic algorithms yielded confirmation of 1538 and 1293 prevalent cases, respectively. The association of AD with asthma was stronger when more stringent AD case definitions were applied. Participants generally reported mild disease (92% with \u226410% maximal body surface area involved) and a high proportion (57%) reported adult\u2010onset disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Self\u2010report of AD diagnosis has good reliability, and future analyses will be strengthened by our ability to conduct sensitivity analyses with refined confirmed AD subgroups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15360","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T16:00:13Z","timestamp":1542988813000},"page":"588-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Diagnosis validation and clinical characterization of atopic dermatitis in Nurses\u2019 Health Study 2"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7388-9475","authenticated-orcid":false,"given":"A.M.","family":"Drucker","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Medicine University of Toronto Toronto ON Canada"},{"name":"Women's College Research Institute and Department of Medicine Women's College Hospital Toronto ON Canada"},{"name":"Department of Dermatology Warren Alpert Medical School of Brown University Providence RI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Dermatology Warren Alpert Medical School of Brown University Providence RI USA"},{"name":"Department of Epidemiology School of Public Health Brown University Providence RI USA"},{"name":"Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.\u2010Q.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Warren Alpert Medical School of Brown University Providence RI USA"},{"name":"Department of Epidemiology School of Public Health Brown University Providence RI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"C.A.","family":"Camargo","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA USA"},{"name":"Department of Emergency Medicine Massachusetts General Hospital and Harvard Medical School Boston MA USA"},{"name":"Department of Epidemiology Harvard T.H. 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