{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:08:53Z","timestamp":1766066933111,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Acquired partial lipodystrophy (APL) is characterized by the gradual symmetrical loss of subcutaneous fat starting from the face, spreading towards the upper part of the body and sparing the lower extremities.<\/jats:p><\/jats:sec>Objective<\/jats:title>We report a 33\u2010year\u2010old woman with facial lipodystrophy, loss of buccal fat pads and breast fat tissue. The subcutaneous fat was preserved in other anatomic regions, and we noted some excess of fat accumulation in the lower abdomen and thighs. She had a low serum level of C3 that was positive for a polyclonal immunoglobulin C3NeF in the serum. She was diagnosed with APL<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We examined fat from lipoatrophic and healthy areas and compared it to subcutaneous fat samples from a healthy control.<\/jats:p><\/jats:sec>Results<\/jats:title>Using scanning electron microscopy, we saw shrunken adipocytes with numerous small lipid droplets detaching from the surface of the adipocytes as compared to the classic aspect of adipose tissue in the control subject where the cytoplasm is occupied by one big lipid droplet. A loss of contact between adipocytes was observed in the APL<\/jats:styled-content> patient when compared to the normal network of adipocytes in the control subject. The healthy fat seemed not affected by lipoatrophy; we observed normal\u2010sized adipocytes, though their surface was not as regular as in the control samples.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The significance and mechanism of the electron microscopic findings are unknown, but they suggest adipocyte shrinkage related to a defect in the retaining triglycerides, which could contribute to the pathogenesis of this disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15366","type":"journal-article","created":{"date-parts":[[2018,11,25]],"date-time":"2018-11-25T14:15:38Z","timestamp":1543155338000},"page":"2188-2191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Abnormal lipid storage related to adipocyte shrinkage in acquired partial lipodystrophy (Barraquer\u2013Simons syndrome)"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-3886","authenticated-orcid":false,"given":"C.","family":"Velter","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg et Clinique Dermatologique Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Messaddeq","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC) CNRS\/INSERM Universit\u00e9 de Strasbourg 1 Rue Laurent Fries, Illkirch France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Levy","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg et Clinique Dermatologique Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Morruzzi","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg et Clinique Dermatologique Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Cribier","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg et Clinique Dermatologique Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Dali\u2010Youcef","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC) CNRS\/INSERM Universit\u00e9 de Strasbourg 1 Rue Laurent Fries, Illkirch France"},{"name":"Laboratoire de Biochimie et Biologie Mol\u00e9culaire H\u00f4pitaux Universitaires de Strasbourg Nouvel H\u00f4pital Civil Strasbourg Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Lipsker","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine H\u00f4pitaux Universitaires de Strasbourg Universit\u00e9 de Strasbourg et Clinique Dermatologique Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra025261"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000111061.69212.59"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2466"},{"key":"e_1_2_6_5_1","first-page":"343","article-title":"Renal disease in partial lipodystrophy","volume":"41","author":"Eisinger AJ","year":"1972","journal-title":"Q J 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