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After exclusion, 948 eligible <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> patients remained for further non\u2010genetic analyses and 1014 for genetic analyses. We included 11 phenotypic, environmental and tumour\u2010specific characteristics, and 20 candidate single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>) as potential predictors for patients with a superficial first <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>. We performed binary logistic multivariable regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that patients with a superficial first <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> were significantly younger, almost two times more often female and 12\u201318 times more likely to have their <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> on the trunk or extremities than patients with a non\u2010superficial first <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>. One <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> (rs12203592), mapped to <jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>4, looked promising (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.83, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.13\u20132.97, <jats:italic>P<\/jats:italic>\u2010value &lt;0.05), but after adjustment for multiple testing, no significant differences in genetic make\u2010up between superficial <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> and non\u2010superficial <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> patients were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that patients with a superficial <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> differ from non\u2010superficial <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> patients with respect to environmental factors (tumour localization as a proxy for <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content> exposure) and phenotypic characteristics (age and sex), but we found no difference in genotype. As superficial <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> patients develop their first <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>s at a younger age, they could be at higher lifetime risk for subsequent skin cancers and therefore be an important group for secondary prevention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15389","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T10:06:16Z","timestamp":1544090776000},"page":"533-540","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Non\u2010genetic and genetic predictors of a superficial first basal cell carcinoma"],"prefix":"10.1111","volume":"33","author":[{"given":"J.A.C.","family":"Verkouteren","sequence":"first","affiliation":[{"name":"Department of Dermatology Erasmus MC Cancer Institute Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.M.","family":"Pardo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus MC Cancer Institute Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.G.","family":"Uitterlinden","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Erasmus MC University Medical Center Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Nijsten","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus MC Cancer Institute Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10830.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.6.681"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.03.010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.07.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000056"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1995.tb01561.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890410049006"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00217.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04804.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700598"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04104.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1998.00431.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03839.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1979.tb01912.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.08.060"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12246.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.08.008"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-015-0082-x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.244"},{"key":"e_1_2_7_21_1","first-page":"19","article-title":"Pathology databanking and biobanking in The Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive","volume":"29","author":"Casparie M","year":"2007","journal-title":"Cell Oncol"},{"key":"e_1_2_7_22_1","volume-title":"World Health Organization Classification of Tumours. 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