{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:19:55Z","timestamp":1761718795543},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Severe nodular acne is characterized by inflammatory nodules and scarring. Their natural evolution and duration are insufficiently investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the evolution and duration of untreated acne nodules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Four\u2010week, single\u2010centre, non\u2010interventional, prospective study in subjects with severe nodular acne on the back. Nodule evolution and duration was assessed using standardized photographs taken twice weekly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 23 subjects were evaluable. Mean age was 25.1\u00a0\u00b1\u00a04.9\u00a0years, 87% were males, and mean acne duration was 9.7\u00a0\u00b1\u00a06.7\u00a0years. At baseline, the overall total nodule count was 132 (mean number: 5.7\u00a0\u00b1\u00a03.0 nodules\/subject). Among others, the following two main pathways were observed: nodules evolving directly into atrophic scars (31.8%) and nodules evolving towards papules into atrophic scars (37.9%). After 4\u00a0weeks, 77.3% of baseline nodules had evolved into atrophic scars. After baseline visit, a total of 247 new nodules (3.1\u00a0\u00b1\u00a02.2 nodules\/week\/subject) with a mean duration of 4.9\u00a0\u00b1\u00a02.6\u00a0days were observed. The mean duration of new nodules was significantly longer in subjects (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>16) with \u22656 new nodules compared to subjects (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>7) with &lt;6 new nodules (5.2\u00a0\u00b1\u00a01.4 vs. 3.6\u00a0\u00b1\u00a00.8\u00a0days; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.008)). There was no correlation between the number of new nodules and acne duration or with the number of baseline nodules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study documents the natural nodule evolution and duration over 4\u00a0weeks and showed in 23 patients the scarring potential of untreated severe nodular acne of the back.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15407","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T05:28:56Z","timestamp":1553059736000},"page":"601-607","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evolution and duration of nodules in severe nodular acne on the back: results from a four\u2010week non\u2010interventional, prospective study"],"prefix":"10.1111","volume":"33","author":[{"given":"A.","family":"Khammari","sequence":"first","affiliation":[{"name":"Dermatology CHU Nantes CRCINA University Nantes 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