{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:36:16Z","timestamp":1790444176743,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:00:00Z","timestamp":1550793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"La Roche-Posay Dermatological Laboratories"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne is a common skin disease that mostly affects teenagers, with a negative impact on quality of life. Recently, adult acne and acne relapses have increased in frequency, for yet unknown reasons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This non\u2010interventional, real\u2010life study sought to investigate the rate of acne relapses and their impact on quality of life and productivity (loss\/absenteeism) among teenagers and adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An online self\u2010administered questionnaire was proposed to \u226515\u2010year\u2010olds suffering from acne who spontaneously consulted their dermatologist. To ensure homogeneous assessment of acne severity, the global acne severity scale was applied. Quality of life was assessed via Cardiff Acne Disability Index (<jats:styled-content style=\"fixed-case\">CADI<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>12\u2010physical score and <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>12\u2010mental score questionnaires. Productivity loss or absenteeism in middle\/high school was estimated based on the number of days off work or school over the last 30 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 1048 questionnaires were considered assessable, with 448 (43%) mild acne, 434 (41%) moderate acne and 166 (16%) severe acne. Overall, 755 (72%) participants were in middle\/high school, 267 (25%) employed and 26 (3%) with no professional activity. Considering the population by age groups, 68% (<jats:italic>n<\/jats:italic> = 716) were \u226420\u2010year\u2010olds and 32% (<jats:italic>n<\/jats:italic> = 332) &gt;20\u2010year\u2010olds, with a mean age of 20.26 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>: 7.43) years. Acne relapses were reported by 44% of respondents. Analyses revealed that poorer quality of life scores was observed in acne relapsers vs. non\u2010relapsers, with a significant difference for <jats:styled-content style=\"fixed-case\">CADI<\/jats:styled-content> scores (<jats:italic>P<\/jats:italic> &lt; 0.01) in &gt;20\u2010year\u2010olds. Acne\u2010related absenteeism was recorded in 5.7% of cases. On multivariate analyses, after adjusting for other variables, acne relapse was proven a significant determinant of absenteeism\/productivity loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This real\u2010life study first demonstrated acne relapse rates of 44%, which appeared to be generation\u2010dependent, affecting 39.9% of \u226420\u2010year\u2010olds vs. 53.3% of &gt;20\u2010year\u2010olds. Acne relapses were significantly associated with impaired quality of life and productivity loss\/absenteeism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15419","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T16:57:30Z","timestamp":1547225850000},"page":"937-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Acne relapses: impact on quality of life and productivity"],"prefix":"10.1111","volume":"33","author":[{"given":"B.","family":"Dreno","sequence":"first","affiliation":[{"name":"Department of Dermatology\u2010Oncology H\u00f4tel\u2010Dieu Nantes University Hospital Centre Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bordet","sequence":"additional","affiliation":[{"name":"DATA CHAMP\u2019 Lyon 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