{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:36:46Z","timestamp":1776155806715,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:00:00Z","timestamp":1550793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Galderma R&D"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The efficacy and safety of methyl aminolevulinate daylight photodynamic therapy (MAL DL\u2010PDT) for actinic keratosis (AK) treatment has previously been demonstrated in several studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate patient\u2010reported outcomes, effectiveness and tolerability of patient self\u2010applied MAL DL\u2010PDT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>An open study was conducted in Germany in patients with thin or non\u2010hyperkeratotic and non\u2010pigmented AK. At baseline, the investigator delimited the target anatomical area and skin preparation was discretionary. On day 1, the patient performed MAL DL\u2010PDT at home, in accordance with instructions (after applying sunscreen and skin preparation by abrasive pad). Patient questionnaires were completed on day 1 and 3 months post\u2010treatment. Effectiveness was assessed by investigator at 3 months. Pain and adverse events (AE) were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients (n = 50) were mostly elderly (mean age: 73.4 years) men (86%). After treatment on day 1, 94% of patients were overall satisfied or very satisfied with the treatment and 98% found the instructions convenient. At 3 months, most patients were satisfied or very satisfied with treatment effectiveness (88%) and aspect of their skin (80%). At 3 months, 62% of overall lesions were completely clear. The main related AEs were mild and expected (erythema, procedural pain and skin burning sensation).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patient self\u2010application of MAL DL\u2010PDT resulted in high levels of patient satisfaction, effectiveness and tolerability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15422","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T16:55:46Z","timestamp":1547225746000},"page":"661-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Methyl aminolevulinate daylight photodynamic therapy applied at home for non\u2010hyperkeratotic actinic keratosis of the face or scalp: an open, interventional study conducted in Germany"],"prefix":"10.1111","volume":"33","author":[{"given":"S.","family":"Karrer","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.A.G.","family":"Aschoff","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Carl Gustav Carus Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Dominicus","sequence":"additional","affiliation":[{"name":"Private Practice Pro Derma Institute for Clinical Studies and Innovative Dermatology D\u00fclmen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kr\u00e4hn\u2010Senftleben","sequence":"additional","affiliation":[{"name":"Private Practice Neu\u2010Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.G.","family":"Gauglitz","sequence":"additional","affiliation":[{"name":"Private Practice M\u00fcnchen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zarzour","sequence":"additional","affiliation":[{"name":"Private Practice Halle (Saale) Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kerrouche","sequence":"additional","affiliation":[{"name":"Galderma R&amp;D Sophia Antipolis France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Chavda","sequence":"additional","affiliation":[{"name":"Galderma R&amp;D Sophia Antipolis France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.\u2010M.","family":"Szeimies","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology Klinikum Vest GmbH Recklinghausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12102"},{"key":"e_1_2_6_3_1","first-page":"1125","article-title":"Review of actinic keratosis. 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