{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:06Z","timestamp":1772160666029,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["IZERZ0_142305"],"award-info":[{"award-number":["IZERZ0_142305"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cutaneous lymphomas (CL) represent a clinically defined group of extranodal non\u2010Hodgkin lymphomas harbouring heterogeneous and incompletely delineated molecular aberrations. Over the past decades, molecular studies have identified several chromosomal aberrations, but the interpretation of individual genomic studies can be challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>With a comprehensive meta\u2010analysis, we aim to delineate genomic alterations for different types of CL and propose a more accurate classification in line with their various pathogenicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed and ISI Web of Knowledge for publications from 1996 to 2016 reporting the investigation of CL for genome\u2010wide copy number alterations, by means of comparative genomic hybridization techniques and whole\u2010genome sequencing and whole\u2010exome sequencing. We then extracted and remapped the available copy number variation (CNV) data from these publications with the same pipeline and performed clustering and visualisation to aggregate samples of similar CNV profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For 449 samples from 22 publications, CNV data were accessible for sample based meta\u2010analysis. Our findings illustrate structural and numerical chromosomal imbalance patterns. Most frequent CNAs were linked to oncogenes or tumour suppressor genes with important roles in the course of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Summary profiles for genomic imbalances, generated from case\u2010specific data, identified complex genomic imbalances, which could discriminate between different subtypes of CL and promise a more accurate classification. The collected data presented in this study are publicly available through the \u2018Progenetix\u2019 online repository.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.15442","type":"journal-article","created":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T15:06:49Z","timestamp":1547910409000},"page":"1062-1075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["DNA copy number imbalances in primary cutaneous lymphomas"],"prefix":"10.1111","volume":"33","author":[{"given":"G.","family":"Gug","sequence":"first","affiliation":[{"name":"University of Medicine and Pharmacy \u201cVictor Babe\u0219\u201d Timi\u0219oara Rom\u00e2nia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Molecular Life Sciences University of Zurich Zurich Switzerland"},{"name":"Swiss Institute of Bioinformatics Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Chiticariu","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201cVictor Babe\u0219\u201d Timi\u0219oara Rom\u00e2nia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Solovan","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201cVictor Babe\u0219\u201d Timi\u0219oara Rom\u00e2nia"},{"name":"Emergency City Hospital University Clinic of Dermatology and Venereology Timi\u0219oara Rom\u00e2nia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Baudis","sequence":"additional","affiliation":[{"name":"Institute of Molecular Life Sciences University of Zurich Zurich Switzerland"},{"name":"Swiss Institute of Bioinformatics Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"354","article-title":"EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer","volume":"90","author":"Willemze R","year":"1997","journal-title":"Blood"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-293050"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08852.x"},{"key":"e_1_2_6_7_1","first-page":"1","article-title":"Extracorporeal photophoresis: an evidence\u2010based analysis","volume":"6","author":"Ontario HQ","year":"2006","journal-title":"Ont Health Technol Assess Ser"},{"key":"e_1_2_6_8_1","first-page":"2212","article-title":"Transformation of mycosis fungoides: clinicopathological and prognostic features of 45 cases. 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