{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:18:31Z","timestamp":1783937911855,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Treatment of erythema multiforme (<jats:styled-content style=\"fixed-case\">EM<\/jats:styled-content>) is not codified. We performed a systematic review of the effect of any topical or systemic treatment on time to healing and frequency of episodes with acute and chronic forms of <jats:styled-content style=\"fixed-case\">EM<\/jats:styled-content> in adults. Four databases (<jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CENTRAL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LILACS<\/jats:styled-content>) and other sources were searched for articles published up to 20 March 2018. Randomized control trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s), observational studies and case series (<jats:italic>n<\/jats:italic> \u2265 10) were considered. From 1558 references, we included one <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> and six case series. The <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 20) showed a significant difference in complete remission of <jats:styled-content style=\"fixed-case\">EM<\/jats:styled-content> with continuous acyclovir vs. placebo over 6 months. One case series found a mean reduction in flare duration with thalidomide for recurrent <jats:styled-content style=\"fixed-case\">EM<\/jats:styled-content> (5.1 vs. 16.2 days; <jats:italic>n<\/jats:italic> = 20). Adverse events were poorly or not reported in included studies. Quality of life was never assessed. One limitation of our study is that we excluded the cases of isolated mucosal <jats:styled-content style=\"fixed-case\">EM<\/jats:styled-content> in order to prevent inclusion of Stevens\u2010Johnson syndrome cases. In conclusion, there is low\u2010level evidence for continuous acyclovir treatment for recurrent <jats:styled-content style=\"fixed-case\">EM<\/jats:styled-content> (one <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>). Evidence for other treatments is only based on retrospective case series. Results for thalidomide, in particular, encourage further research. Data concerning safety are insufficient. <jats:styled-content style=\"fixed-case\">PROSPERO<\/jats:styled-content> registration no. <jats:styled-content style=\"fixed-case\">CRD<\/jats:styled-content>42016053175.<\/jats:p>","DOI":"10.1111\/jdv.15447","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T08:39:33Z","timestamp":1548405573000},"page":"842-849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Interventions for erythema multiforme: a systematic review"],"prefix":"10.1111","volume":"33","author":[{"given":"T.","family":"de Risi\u2010Pugliese","sequence":"first","affiliation":[{"name":"Service de Dermatologie AP\u2010HP H\u00f4pital Henri Mondor Cr\u00e9teil France"},{"name":"Service de Dermatologie et Allergologie AP\u2010HP H\u00f4pital Tenon Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sbidian","sequence":"additional","affiliation":[{"name":"Service de Dermatologie AP\u2010HP H\u00f4pital Henri Mondor Cr\u00e9teil France"},{"name":"EA 7379 EpiDermE (Epidemiology in Dermatology and Evaluation of Therapeutics) Cr\u00e9teil France"},{"name":"INSERM CIC 1430 Paris\u2010Est Creteil University Creteil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ingen\u2010Housz\u2010Oro","sequence":"additional","affiliation":[{"name":"Service de Dermatologie AP\u2010HP H\u00f4pital Henri Mondor Cr\u00e9teil France"},{"name":"EA 7379 EpiDermE (Epidemiology in Dermatology and Evaluation of Therapeutics) Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Le Cleach","sequence":"additional","affiliation":[{"name":"Service de Dermatologie AP\u2010HP H\u00f4pital Henri Mondor Cr\u00e9teil France"},{"name":"EA 7379 EpiDermE (Epidemiology in Dermatology and Evaluation of Therapeutics) Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,28]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"285","article-title":"On diseases of the skin, including the exanthemata","volume":"1","author":"Hebra F","year":"1866","journal-title":"New Sydenham Soc"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)80003-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05348.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690170041005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680220104023"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.046"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00232.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12449"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb05024.x"},{"key":"e_1_2_5_11_1","first-page":"375","article-title":"[Treatment by thalidomide of chronic multiforme erythema: its recurrent and continuous variants. A retrospective study of 26 patients]","volume":"123","author":"Cherouati K","year":"1996","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.05.047"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2006.00307.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.03.013"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.8.1019"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14841"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"e_1_2_5_18_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0","author":"Higgins JPT"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.10.023"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90062-U"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000249598"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.15447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.15447","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T15:39:32Z","timestamp":1694360372000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.15447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,28]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/jdv.15447"],"URL":"https:\/\/doi.org\/10.1111\/jdv.15447","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,28]]},"assertion":[{"value":"2018-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}