{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:43:48Z","timestamp":1777963428488,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Methylchloroisothiazolinone (<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>)\/methylisothiazolinone (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>) (Kathon<jats:sup>\u00ae<\/jats:sup> CG) is a common preservative used in industrial products, owing to its strong biocide effect. Contact allergy to <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> has been reported in different occupations, including mechanics, hairdressers and healthcare workers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To retrospectively analyse the temporal trend of <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> sensitization in north\u2010eastern Italy and to evaluate the associations with occupations in our geographical area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 1996 to 2016, 27\u00a0381 patients with suspected allergic contact dermatitis were patch tested in eight departments of Dermatology or Occupational Medicine in north\u2010eastern Italy. Individual characteristics were collected through a standardized questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall prevalence of <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> sensitization was 4.2%, with the highest prevalence found in women and in patients younger than 25\u00a0years. <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> sensitization was significantly associated with atopic eczema (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.34, 95% CI: 1.10\u20131.70), hand\/forearm dermatitis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.20, 95% CI: 1.05\u20131.36) and face dermatitis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.30, 95% CI: 1.10\u20131.40). There was a significant association between <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> sensitization and chemical processing workers (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.74, 95% CI: 1.03\u20132.94), while mechanics and healthcare workers resulted more sensitized to this hapten only in the last 3\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sensitization to <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> is rising in the last years in Triveneto region, the \u2018epidemic\u2019 of sensitization to <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> is mainly driven by extra\u2010occupational dermatitis, and sensitization in some occupational groups is emerging only in the last years. A full labelling is compulsory for all products that contain isothiazolinones, to permit to identify the culprit agent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15453","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T05:24:36Z","timestamp":1548825876000},"page":"912-917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Contact allergy to methylchloroisothiazolinone\/methylisothiazolinone in north\u2010eastern Italy: a temporal trend from 1996 to 2016"],"prefix":"10.1111","volume":"33","author":[{"given":"A.","family":"Dusefante","sequence":"first","affiliation":[{"name":"Clinical Unit of Occupational Medicine University of Trieste Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mauro","sequence":"additional","affiliation":[{"name":"Clinical Unit of Occupational Medicine University of Trieste Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Belloni Fortina","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Unit University of Padua Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.T.","family":"Corradin","sequence":"additional","affiliation":[{"name":"Ospedale Santa Maria degli Angeli Pordenone Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7717-0417","authenticated-orcid":false,"given":"F.","family":"Larese Filon","sequence":"additional","affiliation":[{"name":"Clinical Unit of Occupational Medicine University of Trieste Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176083"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10523.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2016.2951"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000288"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12741"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12217"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12333"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02074.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12385"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000205"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000158"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13992"},{"key":"e_1_2_7_14_1","first-page":"287","article-title":"Terminology of contact dermatitis","volume":"50","author":"Wilkinson D","year":"1970","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14063"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12937"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02075.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12733"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13028"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13133"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12379"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12249"},{"key":"e_1_2_7_23_1","unstructured":"European Commission.Scientific Committee on Consumer Safety. 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