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Recently, a 31\u2010gene expression profile (DecisionDx\u2010Melanoma) test has shown promising results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the early prognostic performance of a genetic signature in a multicentre prospectively evaluated cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Inclusion of patients with <jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content> stages <jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> conducted between April 2015 and December 2016. All patients were followed up prospectively to assess their risk of relapse. Prognostic performance of this test was evaluated individually and later combined with the <jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content> staging system. Prognostic accuracy of disease\u2010free survival was determined using Kaplan\u2013Meier curves and Cox regression analysis. Results of the gene expression profile test were designated as Class 1 (low risk) and Class 2 (high risk).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median follow\u2010up time was 26\u00a0months (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 22\u201330). The gene expression profile test was performed with 86 patients; seven had developed metastasis (8.1%) and all of them were in the Class 2 group, representing 21.2% of this group. Gene expression profile was an independent prognostic factor for relapse as indicated by multivariate Cox regression analysis, adjusted for <jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content> stages and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This prospective multicentre cohort study, performed in a Spanish Caucasian cohort, shows that this 31\u2010gene expression profile test could correctly identify patients at early <jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content> stages who are at greater risk of relapse. We believe that gene expression profile in combination with the <jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content> staging system could well improve the detection of patients who need intensive surveillance and optimize follow\u2010up strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15454","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T13:22:58Z","timestamp":1548940978000},"page":"857-862","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Early outcome of a 31\u2010gene expression profile test in 86 <scp>AJCC<\/scp> stage <scp>IB<\/scp>\u2010<scp>II<\/scp> melanoma patients. A prospective multicentre cohort study"],"prefix":"10.1111","volume":"33","author":[{"given":"S.","family":"Podlipnik","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Cl\u00ednic de Barcelona University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Carrera","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Cl\u00ednic de Barcelona University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Boada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari Germans Trias i Pujol Badalona, Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.A.","family":"Richarz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari Germans Trias i Pujol Badalona, Barcelona 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