{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T01:55:47Z","timestamp":1782266147133,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autoimmune bullous dermatoses (<jats:styled-content style=\"fixed-case\">AIBD<\/jats:styled-content>s) in children are uncommon, and their long\u2010term evolution remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this retrospective study was to characterize the long\u2010term prognosis of <jats:styled-content style=\"fixed-case\">AIBD<\/jats:styled-content>s that started during childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a monocentric retrospective study, in the French dermatology centre, by including all children affected by <jats:styled-content style=\"fixed-case\">AIBD<\/jats:styled-content>s. The long\u2010term outcome was obtained through a phone call questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010three patients were included from January 1993 to December 2015, 34 female and 29 males: 27 Linear immunoglobulin A disease (<jats:styled-content style=\"fixed-case\">LAD<\/jats:styled-content>), 12 bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>), 12 pemphigus, 8 herpetiform dermatitis (<jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content>) and 4 epidermolysis bullosa aquisita (<jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content>). The mean age was 4.7\u00a0years old. Twenty\u2010five patients were lost during the follow\u2010up. For the 38 remaining patients, the mean follow\u2010up duration for all pathologies was 6.6\u00a0years. Twenty\u2010nine of them had at least one relapse. Late relapses were observed in two cases of <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content> and six cases of pemphigus (7\u201334\u00a0months). The mean treatment duration was 30.6\u00a0months with variability according to the <jats:styled-content style=\"fixed-case\">AIBD<\/jats:styled-content>s. Topical corticosteroids were used alone, effectively, for seven patients and in association with other treatment in 19 patients in complete remission. Complete remission was noted in 34\/38 children with a follow\u2010up of 4.4\u00a0years (0.08\u201319.5). The mean duration to complete remission was 30.5\u00a0months (6\u2013114\u00a0months). Late nasal synechiae were reported in one <jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content> only. There was no significant associated comorbidity, but an association with a primary immune deficiency (<jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content>) was observed in two cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Childhood <jats:styled-content style=\"fixed-case\">AIBD<\/jats:styled-content>s appear to be of good overall prognosis but a long\u2010term follow\u2010up is mandatory, as relapses can be late, except for <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>. The use of topical corticosteroids is frequently effective alone or in association. The association with <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content> leads to think about the possibility of a possible underlying dysimmunity in the child.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15456","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T13:23:26Z","timestamp":1548941006000},"page":"1158-1163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Long\u2010term evolving profile of childhood autoimmune blistering diseases: Retrospective study on 38 children"],"prefix":"10.1111","volume":"33","author":[{"given":"A.","family":"Welfringer\u2010Morin","sequence":"first","affiliation":[{"name":"Department of Dermatology and Reference Centre for Genodermatoses and Rare Skin Diseases (MAGEC), H\u00f4pital Universitaire Necker\u2010Enfants Malades, Assistance publique\u2010H\u00f4pitaux de Paris, Universit\u00e9 Paris Descartes \u2010 Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bekel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Reference Centre for Genodermatoses and Rare Skin Diseases (MAGEC), H\u00f4pital Universitaire Necker\u2010Enfants Malades, Assistance publique\u2010H\u00f4pitaux de Paris, Universit\u00e9 Paris Descartes \u2010 Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Bellon","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Reference Centre for Genodermatoses and Rare Skin Diseases (MAGEC), H\u00f4pital Universitaire Necker\u2010Enfants Malades, Assistance publique\u2010H\u00f4pitaux de Paris, Universit\u00e9 Paris Descartes \u2010 Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gantzer","sequence":"additional","affiliation":[{"name":"Department 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