{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:18:07Z","timestamp":1791508687065,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There have been a number of case reports and small clinical trials reporting promising outcomes of Janus Kinase (<jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>) inhibitors tofacitinib, ruxolitinib and baricitinib for alopecia areata (<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>). The majority of the literature to date is based on small volume data, with a lack of definitive evidence or guidelines. To determine the expected response of <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content> inhibitor therapy and factors which influence response and recurrence rates. A systematic review and meta\u2010analysis was performed according to <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content> guidelines. From 30 studies and 289 cases, there were 72.4% responders, good responders 45.7% and partial responders 21.4%. Mean time to initial hair growth was 2.2\u00a0\u00b1\u00a06.7\u00a0months, and time to complete hair regrowth was 6.7\u00a0\u00b1\u00a02.2\u00a0months. All 37 recurrences occurred when treatment was ceased after 2.7\u00a0months. Oral route was significantly associated with response to treatment compared to topical therapy. No difference was found between paediatric and adult cases in proportion of responses. There is promising low\u2010quality evidence regarding the effectiveness of <jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content> inhibitors in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>. Future large\u2010sized randomized studies are required to confirm findings.<\/jats:p>","DOI":"10.1111\/jdv.15489","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T14:43:42Z","timestamp":1550155422000},"page":"850-856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":197,"title":["JAK inhibitors for alopecia areata: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"33","author":[{"given":"K.","family":"Phan","sequence":"first","affiliation":[{"name":"Department of Dermatology Liverpool Hospital Sydney NSW Australia"},{"name":"Faculty of Medicine University of New South Wales Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.F.","family":"Sebaratnam","sequence":"additional","affiliation":[{"name":"Department of Dermatology Liverpool Hospital Sydney NSW Australia"},{"name":"Faculty of Medicine University of New South Wales Sydney 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