{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T22:31:56Z","timestamp":1769725916274,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The European Nail Society"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nail changes due to systemic drugs are common, especially with anticancer treatments due to involvement of nail plate, nail bed and periungual area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the pattern of nail changes occurring due to chemotherapy in patients suffering from various malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A prospective, observational study was conducted at various health care centres, Nashik, India, for 15\u00a0months. The timing of administration of chemotherapy and onset of nail changes were recorded and evaluated by a dermatologist at regular interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 129 diagnosed cases of various malignancies who received chemotherapy were included. The most common malignancy noted was breast cancer, that is <jats:italic>n<\/jats:italic>\u00a0=\u00a042 (32.5%) followed by oral cancer, that is <jats:italic>n<\/jats:italic>\u00a0=\u00a024 (18.6%). Chemotherapy agents included taxanes (<jats:italic>n<\/jats:italic>\u00a0=\u00a054), cyclophosphamide (<jats:italic>n<\/jats:italic>\u00a0=\u00a042) and prednisolone (<jats:italic>n<\/jats:italic>\u00a0=\u00a028). Nail changes were noted in 92 patients (71.3%). The most common nail changes observed were chromonychia (<jats:italic>n<\/jats:italic>\u00a0=\u00a070, 54.26%), followed by nail dystrophy (<jats:italic>n<\/jats:italic>\u00a0=\u00a038, 29.45%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Nail toxicity is quite common side effect of anticancer agents. Nail changes due to chemotherapy depend on the nail structure involved and the severity of insult. Awareness among dermatologists and oncologists of these nail changes and their culprit agent can promote early diagnosis and may avoid inadvertent measures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15508","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T10:46:15Z","timestamp":1552041975000},"page":"1398-1404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Nail changes due to chemotherapy: a prospective observational study of 129 patients"],"prefix":"10.1111","volume":"33","author":[{"given":"V.","family":"Zawar","sequence":"first","affiliation":[{"name":"Department of Dermatology MVP's Dr.Vasantrao Pawar Medical College Nashik India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bondarde","sequence":"additional","affiliation":[{"name":"Shatabdi Multispecialty Hospital Nashik India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pawar","sequence":"additional","affiliation":[{"name":"Department of Dermatology MVP's Dr.Vasantrao Pawar Medical College Nashik India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sankalecha","sequence":"additional","affiliation":[{"name":"B\u2010Wing, Suyojit City Center Nashik India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199921030-00004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.3.1.57"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304010-00004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-007-0318-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1684\/bdc.2013.1709"},{"key":"e_1_2_7_7_1","unstructured":"MateusC ArnaultJP VerschooreM et\u00a0al.\u00c9tude prospective des eff ets secondaires cutan\u00e9s des chimioth\u00e9rapies et agents anticanc\u00e9reux cibl\u00e9s. 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