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Tissue eosinophilia (number of eosinophils per high\u2010power field (<jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content>)) was investigated in skin biopsies obtained from the following groups of patients who demonstrated: (i) in\u00a0vitro assay and telephone interview\u2010validated cutaneous drug reactions (true<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>); (ii) initial clinical diagnosis of<jats:styled-content style=\"fixed-case\">ACDR<\/jats:styled-content>but drug aetiology was excluded by in\u00a0vitro assay and telephone interview (false<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>); and (iii) non\u2010drug\u2010associated cutaneous eruptions, skin tumours and nevi, randomly selected for evaluation (control).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly higher number of eosinophils per<jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content>was observed in the false<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>compared to the true<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). The false<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>group demonstrated a higher number of eosinophils (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) while the true<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>group eosinophils\u2019 number was not significantly higher as compared to control (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.2032).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tissue eosinophilia is not a reliable indicator of<jats:styled-content style=\"fixed-case\">ACDR<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15509","type":"journal-article","created":{"date-parts":[[2019,2,16]],"date-time":"2019-02-16T06:28:09Z","timestamp":1550298489000},"page":"1152-1157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nested case\u2013control study investigating the diagnostic role of tissue eosinophilia in adverse cutaneous drug reactions"],"prefix":"10.1111","volume":"33","author":[{"given":"L.","family":"Samuelov","sequence":"first","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center Affiliated with Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nathan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center Affiliated with Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Slutsky","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center Affiliated with Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Fruchter","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center Affiliated with Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gat","sequence":"additional","affiliation":[{"name":"Institute of Pathology Tel Aviv Sourasky Medical Center Affiliated with Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Sprecher","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center Affiliated with Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center Affiliated with Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.2686"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03260350022021"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb01017.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-018-0778-6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00350"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411103311906"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5163129"},{"key":"e_1_2_5_9_1","first-page":"765","article-title":"Rates of cutaneous reactions to drugs","volume":"137","author":"Bigby M","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/inf.1970.2.issue-1.05"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1999.00096.x"},{"key":"e_1_2_5_12_1","first-page":"452","article-title":"Adverse drug reactions in the elderly","volume":"448","author":"Nolan L","year":"1989","journal-title":"Br J Hosp Med"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102060-00001"},{"key":"e_1_2_5_14_1","first-page":"1208","article-title":"Prevalence of cutaneous disorders in a population of HIV\u2010infected patients. 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