{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T03:17:18Z","timestamp":1761621438518},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Conventional photodynamic therapy (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>) with methylaminolevulinic acid (<jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>) and daylight <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> have demonstrated similar efficacy in the treatment of actinic keratosis (<jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>). The reason for the use of daylight is to reduce pain during illumination but daylight has the limitation of the weather conditions. The difference in the doses of red light applied between these two methods suggests that an intermediate dose with red light conventional illumination could be effective in <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the efficiency of conventional <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> with half\u2010time conventional red light illumination in patients with multiple <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Adult patients with more than five symmetrically distributed <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> were selected. After randomization, one area was treated with conventional <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> (Aktilite<jats:sup>\u00ae<\/jats:sup>, 630\u00a0nm, 37\u00a0J\/cm<jats:sup>2<\/jats:sup>, 8\u00a0min), while the contralateral was illuminated half time (Aktilite<jats:sup>\u00ae<\/jats:sup>, 630\u00a0nm, 37\u00a0J\/cm<jats:sup>2<\/jats:sup>, 4\u00a0min). Patients evaluated pain in each different side. Patients were evaluated at baseline, 3 and 6\u00a0months after <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> treatment by a blinded dermatologist. A questionnaire to be done at home 24\u00a0h after completing treatment was deliver to the patients to evaluate any side\u2010effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 774 lesions were treated, 385 with conventional <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> and 389 with half\u2010time <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). Conventional <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> was 85% of complete response of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> (327\/385) at 3\u00a0months, and half\u2010time <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> was 82% (319\/389). At 6\u00a0months, conventional <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> was 70% (268\/385) of complete response and half\u2010time <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> was 65% (252\/389). Pain during illumination was significantly lower in the <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> with the half\u2010time protocol with a mean of 5.59 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 1.48) vs. 6.41 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 1.66) in conventional <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>. No difference in adverse effects was found between protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Conventional <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> with half\u2010time illumination in multiple actinic keratosis is as effective as complete time illumination and decreased pain significantly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15566","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T06:45:15Z","timestamp":1552545915000},"page":"1529-1534","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Split\u2010face study comparing conventional <scp>MAL<\/scp> photodynamic therapy in multiple actinic keratosis with complete time vs. half\u2010time red light <scp>LED<\/scp> conventional illumination"],"prefix":"10.1111","volume":"33","author":[{"given":"M.","family":"Fern\u00e1ndez\u2010Guarino","sequence":"first","affiliation":[{"name":"Dermatology Department Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Fonda Pascual","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lizuain Gomez","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Harto Casta\u00f1o","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Ja\u00e9n Olasolo","sequence":"additional","affiliation":[{"name":"Dermatology 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