{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:29:02Z","timestamp":1762867742661},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Incidence of anal carcinoma is increased in people living with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PLWH<\/jats:styled-content>). Due to the improved life expectancy in <jats:styled-content style=\"fixed-case\">PLWH<\/jats:styled-content>, identifying appropriate prevention strategies for non\u2010<jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>\u2010defining cancer types such as anal carcinoma has become a priority in managing <jats:styled-content style=\"fixed-case\">PLWH<\/jats:styled-content> today.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to evaluate anal cytology assessment as screening tool for anal dysplasia and\/or carcinoma in <jats:styled-content style=\"fixed-case\">PLWH<\/jats:styled-content>, regardless of gender or sexual orientation. Additionally, we investigated the correlation between cancer risk factors and abnormal screening results in our patient cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>People living with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> from the Interdisciplinary <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> Centre of the University Hospital rechts der Isar in Munich, Germany (<jats:styled-content style=\"fixed-case\">IZAR<\/jats:styled-content>), were screened for anal carcinoma by single cytobrush examination and anal Papanicolaou (<jats:styled-content style=\"fixed-case\">PAP<\/jats:styled-content>) smear assessment from 2013 to 2015. Patients with abnormal <jats:styled-content style=\"fixed-case\">PAP<\/jats:styled-content> smear result were offered a follow\u2010up examination after 12 months. Differences between two groups were tested for statistical significance using Student's <jats:italic>t<\/jats:italic>\u2010test and Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test, as appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 101 <jats:styled-content style=\"fixed-case\">PLWH<\/jats:styled-content> were included. 26.7% of subjects (<jats:italic>n<\/jats:italic> = 27) were <jats:styled-content style=\"fixed-case\">PAP IIID<\/jats:styled-content>, and 9.9% (<jats:italic>n<\/jats:italic> = 10) were <jats:styled-content style=\"fixed-case\">PAP IV<\/jats:styled-content>a. Seven female subjects had an abnormal finding at screening. Smoking was significantly associated with abnormal findings at screening (<jats:italic>P<\/jats:italic> = 0.005). In addition, our study found an association between sexually transmitted infections (<jats:styled-content style=\"fixed-case\">STI<\/jats:styled-content>) and anal dysplasia. Condylomata acuminata were increased in subjects with <jats:styled-content style=\"fixed-case\">PAP IIID<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PAP IV<\/jats:styled-content>a (<jats:italic>P<\/jats:italic> = 0.045). Reactive syphilis serology was found to be significantly associated with abnormal screening results (<jats:italic>P<\/jats:italic> = 0.016), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results demonstrate that smoking and two common <jats:styled-content style=\"fixed-case\">STI<\/jats:styled-content>s, condylomata acuminata and syphilis, are risk factors associated with advanced anal intraepithelial neoplasia (<jats:styled-content style=\"fixed-case\">AIN<\/jats:styled-content>) stages in our <jats:styled-content style=\"fixed-case\">PLWH<\/jats:styled-content> cohort. While further analysis is needed to determine diagnostic guidelines concerning <jats:styled-content style=\"fixed-case\">AIN<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PLWH<\/jats:styled-content>, these results suggest that interdisciplinary lifestyle prevention strategies are required to reduce the risk factors for <jats:styled-content style=\"fixed-case\">AIN<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PLWH<\/jats:styled-content> in an outpatient setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15575","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T08:10:00Z","timestamp":1552983000000},"page":"1595-1601","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of anal carcinoma screening in male and female <scp>HIV<\/scp> patients at an interdisciplinary <scp>HIV<\/scp> therapy 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